Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKGWAH)

Drug Name
MESULERGINE Drug Info
Synonyms
Mesulergine; Mesulerginum; Mesulergina; Mesulergine [INN]; Mesulerginum [INN-Latin]; UNII-SML95FK06I; Mesulergina [INN-Spanish]; 64795-35-3; N'-(1,6-Dimethylergolin-8alpha-yl)-N,N-dimethylsulfamide; SML95FK06I; CQ 32085; CHEMBL12314; C18H26N4O2S; CHEBI:73378; 3-(1,6-Dimethyl-8alpha-ergolinyl)-1,1-dimethylsulfamid; NCGC00163168-01; DSSTox_RID_81540; DSSTox_CID_26324; DSSTox_GSID_46324; CU-32085; N'-[(8alpha)-1,6-dimethylergolin-8-yl]-N,N-dimethylsulfuric diamide; CAS-64795-35-3; AC1L2AKM; Biomol-NT_000077; AC1Q6V4R; GTPL206
Cross-matching ID
PubChem CID
68848
ChEBI ID
CHEMBL73378
CAS Number
CAS 64795-35-3
TTD Drug ID
D0K5NZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.00 7.80e-3 34/36 (94.44%) MCM4;RFC5;MCM6;...
Steroid biosynthesis 1.98 7.80e-3 19/20 (95%) MSMO1;DHCR24;EBP;...
Pyruvate metabolism -1.65 4.94e-2 41/47 (87.23%) ACACB;MDH2;PCK2;...
Type I diabetes mellitus -1.67 3.97e-2 38/43 (88.37%) CD80;CD86;IL2;...
Pertussis -1.67 4.11e-2 64/76 (84.21%) IRF3;C4BPA;CASP7;...
Fatty acid degradation -1.68 4.14e-2 40/43 (93.02%) HADHA;ACADSB;ALDH7A1;...
Hematopoietic cell lineage -1.71 2.55e-2 90/99 (90.91%) CSF1R;CD8A;CSF2;...
Histidine metabolism -1.72 2.56e-2 16/22 (72.73%) ALDH7A1;HDC;ALDH9A1;...
Mitophagy -1.72 2.72e-2 56/68 (82.35%) CALCOCO2;RHOT1;GABARAPL2;...
NOD-like receptor signaling pathway -1.72 2.90e-2 145/181 (80.11%) NFKBIB;IRF3;CYBB;...
Tryptophan metabolism -1.74 2.33e-2 35/42 (83.33%) HADHA;ALDH7A1;TDO2;...
beta-Alanine metabolism -1.75 2.42e-2 25/30 (83.33%) GAD2;HADHA;ALDH7A1;...
Allograft rejection -1.75 2.52e-2 32/38 (84.21%) HLA-DQA1;HLA-F;CD80;...
Inflammatory bowel disease -1.75 2.75e-2 58/65 (89.23%) IL4;IL18;TBX21;...
Ribosome -1.76 2.78e-2 113/158 (71.52%) RPL38;MRPL33;RPS2;...
Osteoclast differentiation -1.77 2.96e-2 117/127 (92.13%) MAP2K1;MAPK9;TYK2;...
Th17 cell differentiation -1.81 2.42e-2 95/107 (88.79%) STAT5B;IL4;TGFBR1;...
Amoebiasis -1.85 1.38e-2 99/102 (97.06%) LAMA3;ITGAM;PIK3R1;...
Viral protein interaction with cytokine and cytokine re... -1.89 6.05e-3 84/100 (84%) IL2;IL18R1;CCR1;...
TNF signaling pathway -1.96 7.26e-3 103/112 (91.96%) SOCS3;TNFAIP3;CFLAR;...
Rheumatoid arthritis -2.00 3.02e-3 78/93 (83.87%) ATP6V1F;ATP6V0E1;ITGAL;...
NF-kappa B signaling pathway -2.03 4.03e-3 90/104 (86.54%) TNFAIP3;CFLAR;PIAS4;...
Th1 and Th2 cell differentiation -2.07 6.05e-3 80/92 (86.96%) STAT5B;IL4;TBX21;...
Graft-versus-host disease -2.17 0.00e+0 32/42 (76.19%) HLA-DQA1;HLA-F;CD80;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H