Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKI1F6)

Drug Name
Halometasone Drug Info
Synonyms Sicorten (TN)
Cross-matching ID
PubChem CID
9846332
ChEBI ID
CHEMBL135724
CAS Number
CAS 50629-82-8
TTD Drug ID
D0C8HR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
PPAR signaling pathway 2.07 0.00e+0 66/74 (89.19%) ACSL1;HMGCS1;CD36;...
Synthesis and degradation of ketone bodies 2.06 0.00e+0 9/10 (90%) HMGCS1;HMGCS2;ACAT1;...
Complement and coagulation cascades 2.01 3.53e-3 76/85 (89.41%) CFH;CFB;SERPINE1;...
Staphylococcus aureus infection 1.99 5.30e-3 72/95 (75.79%) KRT15;CFH;CFB;...
Steroid biosynthesis 1.89 1.48e-2 19/20 (95%) CYP51A1;DHCR7;DHCR24;...
Nicotinate and nicotinamide metabolism 1.89 1.59e-2 25/35 (71.43%) NNMT;CD38;SIRT3;...
Citrate cycle (TCA cycle) 1.84 1.67e-2 30/30 (100%) PCK1;SDHD;IDH1;...
Fatty acid degradation 1.83 1.72e-2 40/43 (93.02%) ECI2;ADH1B;ACSL1;...
Adipocytokine signaling pathway 1.77 2.24e-2 64/69 (92.75%) NFKBIA;ACSL1;PRKAG2;...
Drug metabolism 1.76 2.23e-2 78/151 (51.66%) ADH1B;GUSB;DPYD;...
Proximal tubule bicarbonate reclamation 1.73 3.37e-2 21/23 (91.3%) PCK1;ATP1B3;FXYD2;...
Pyruvate metabolism 1.72 3.62e-2 41/47 (87.23%) ADH1B;ACAT1;PCK1;...
Terpenoid backbone biosynthesis 1.71 3.99e-2 18/22 (81.82%) HMGCS1;HMGCS2;ACAT1;...
Steroid hormone biosynthesis 1.70 4.24e-2 43/61 (70.49%) SRD5A1;UGT2B28;HSD17B8;...
RNA polymerase -1.95 4.59e-3 23/31 (74.19%) POLR1E;POLR2C;POLR2B;...
IL-17 signaling pathway -2.07 9.18e-3 84/94 (89.36%) IFNG;CXCL3;TRAF4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H