Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKIE9C)

Drug Name
JNJ-26481585 Drug Info
Synonyms
875320-29-9; N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide; UNII-9BJ85K1J8S; Quisinostat (JNJ-26481585); JNJ26481585; 9BJ85K1J8S; N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide; 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide; N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carboxamide
Cross-matching ID
PubChem CID
11538455
ChEBI ID
CHEMBL2105763
CAS Number
CAS 875320-29-9
TTD Drug ID
D09XIZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Synaptic vesicle cycle 2.45 0.00e+0 63/78 (80.77%) ATP6V1D;STXBP1;ATP6V0D1;...
Oxidative phosphorylation 2.25 0.00e+0 93/133 (69.92%) ATP6V1D;ATP6V0D1;NDUFB6;...
Lysosome 2.11 0.00e+0 115/128 (89.84%) LIPA;GM2A;FUCA1;...
Steroid biosynthesis 2.05 0.00e+0 19/20 (95%) LIPA;DHCR7;MSMO1;...
Collecting duct acid secretion 2.03 2.19e-3 22/27 (81.48%) ATP6V1D;ATP6V0D1;ATP6V1A;...
Vibrio cholerae infection 1.99 3.66e-3 44/50 (88%) ATP6V1D;PRKACA;ATP6V0D1;...
Aldosterone-regulated sodium reabsorption 1.88 6.27e-3 34/37 (91.89%) ATP1B1;INSR;ATP1A1;...
Citrate cycle (TCA cycle) 1.84 9.60e-3 30/30 (100%) MDH1;IDH3A;DLD;...
Fructose and mannose metabolism 1.84 8.53e-3 30/33 (90.91%) ALDOC;TIGAR;ALDOB;...
Glycerolipid metabolism 1.82 1.10e-2 44/61 (72.13%) LPIN1;AKR1A1;AKR1B10;...
Cholesterol metabolism 1.78 1.79e-2 44/50 (88%) LIPA;NPC1;NPC2;...
Carbohydrate digestion and absorption 1.77 1.65e-2 37/47 (78.72%) ATP1B1;ATP1A1;PIK3R3;...
Pentose phosphate pathway 1.77 1.52e-2 25/30 (83.33%) ALDOC;TKTL1;G6PD;...
Pyruvate metabolism 1.73 2.12e-2 41/47 (87.23%) MDH1;AKR1A1;DLD;...
Glycolysis / Gluconeogenesis 1.73 1.97e-2 56/67 (83.58%) ALDOC;ALDOB;AKR1A1;...
Valine, leucine and isoleucine degradation 1.72 1.99e-2 42/48 (87.5%) HMGCS1;HIBCH;DLD;...
Regulation of lipolysis in adipocytes 1.70 2.19e-2 52/55 (94.55%) GNAI2;ADRB2;PRKACA;...
Huntington disease 1.70 2.32e-2 233/306 (76.14%) TUBB2A;SLC25A4;PIK3R4;...
Other glycan degradation 1.69 2.42e-2 13/18 (72.22%) FUCA1;NEU1;MAN2B1
Parkinson disease 1.69 2.58e-2 176/249 (70.68%) TUBB2A;SLC25A4;KIF5C;...
SNARE interactions in vesicular transport 1.69 2.51e-2 19/33 (57.58%) STX7;SNAP29;STX1A;...
Autophagy 1.68 2.74e-2 113/169 (66.86%) PIK3R4;PRKACA;RRAGA;...
Prion disease 1.67 3.00e-2 209/273 (76.56%) TUBB2A;SLC25A4;KIF5C;...
Ether lipid metabolism 1.63 4.07e-2 32/49 (65.31%) PLAAT3;PAFAH1B3;PLD3;...
mTOR signaling pathway 1.63 3.95e-2 114/154 (74.03%) ATP6V1D;RRAGA;LPIN1;...
Glycerophospholipid metabolism 1.63 3.97e-2 71/98 (72.45%) GPD1L;PLA2G15;PLAAT3;...
Mismatch repair 1.61 4.35e-2 22/23 (95.65%) RPA3;PCNA;POLD4;...
ECM-receptor interaction -1.76 3.80e-2 80/88 (90.91%) COL6A1;ITGA4;CD44;...
Pyrimidine metabolism -1.85 2.63e-2 40/56 (71.43%) RRM2;DTYMK;ENTPD1;...
One carbon pool by folate -1.91 2.63e-2 15/20 (75%) GART;MTHFD2L;MTHFD2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H