Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKJ393)

Drug Name
Pemfexy Drug Info
Cross-matching ID
PubChem CID
135410875
TTD Drug ID
D0C7LD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.64 0.00e+0 34/36 (94.44%) RFC3;MCM5;FEN1;...
p53 signaling pathway 2.16 0.00e+0 63/73 (86.3%) CCND3;CCNE2;RRM2;...
Mismatch repair 2.16 0.00e+0 22/23 (95.65%) RFC3;MSH6;LIG1;...
Cell cycle 2.15 0.00e+0 110/124 (88.71%) CCND3;CCNE2;CCNA2;...
Fanconi anemia pathway 1.96 1.61e-3 36/54 (66.67%) FANCI;BLM;BRCA1;...
Homologous recombination 1.94 2.68e-3 35/41 (85.37%) BLM;BRCA1;RAD51;...
Hepatitis C 1.88 4.59e-3 139/157 (88.54%) MX1;IFIT1;PPP2R1B;...
Pyrimidine metabolism 1.88 4.02e-3 40/56 (71.43%) RRM2;RRM1;CTPS1;...
Oocyte meiosis 1.83 9.82e-3 90/129 (69.77%) CCNE2;CDK1;PPP2R1B;...
Nucleotide excision repair 1.81 9.64e-3 40/47 (85.11%) RFC3;LIG1;RFC2;...
Focal adhesion 1.75 2.12e-2 180/201 (89.55%) CCND3;SPP1;LAMC2;...
Progesterone-mediated oocyte maturation 1.74 2.34e-2 75/100 (75%) CCNA2;CDK1;CDC25A;...
Base excision repair 1.72 2.78e-2 29/33 (87.88%) FEN1;LIG1;POLE2;...
Spliceosome 1.69 3.27e-2 101/150 (67.33%) HSPA2;SRSF3;SF3A3;...
Epstein-Barr virus infection 1.69 3.05e-2 189/202 (93.56%) CCND3;CCNE2;CCNA2;...
Drug metabolism 1.68 3.21e-2 78/151 (51.66%) RRM2;CES1;RRM1;...
Small cell lung cancer 1.64 4.11e-2 90/92 (97.83%) CCNE2;LAMC2;PTGS2;...
Bacterial invasion of epithelial cells 1.64 4.06e-2 59/77 (76.62%) CTNNB1;CAV2;CAV1;...
Measles 1.63 3.89e-2 133/139 (95.68%) CCND3;CCNE2;MX1;...
Viral carcinogenesis 1.63 3.82e-2 149/203 (73.4%) CCND3;CCNE2;CCNA2;...
Hippo signaling pathway 1.61 4.40e-2 120/186 (64.52%) CCND3;AREG;PPP2R1B;...
Human papillomavirus infection 1.59 4.60e-2 284/331 (85.8%) CCND3;CCNE2;SPP1;...
Glycerophospholipid metabolism -1.71 3.24e-2 71/98 (72.45%) LPIN2;LPCAT1;PLAAT3;...
Asthma -1.72 3.38e-2 25/31 (80.65%) HLA-DOB;IL3;EPX;...
SNARE interactions in vesicular transport -1.73 3.29e-2 19/33 (57.58%) STX3;VAMP1;STX8;...
Phagosome -1.75 2.72e-2 118/152 (77.63%) ATP6V0D1;SCARB1;ATP6V0A4;...
Antigen processing and presentation -1.75 2.75e-2 60/78 (76.92%) HLA-F;NFYB;HLA-E;...
Glycerolipid metabolism -1.76 2.25e-2 44/61 (72.13%) LIPF;GLA;ALDH3A2;...
Protein processing in endoplasmic reticulum -1.76 2.48e-2 127/171 (74.27%) HSPA1L;RAD23B;NFE2L2;...
Mineral absorption -1.77 2.49e-2 48/60 (80%) FTL;FXYD2;STEAP1;...
Oxidative phosphorylation -1.83 5.90e-3 93/133 (69.92%) NDUFA4;NDUFB4;ATP6V1A;...
Other glycan degradation -1.86 3.37e-3 13/18 (72.22%) FUCA1;HEXA;GLB1;...
Rheumatoid arthritis -1.90 1.97e-3 78/93 (83.87%) ATP6V1A;FLT1;ICAM1;...
Ether lipid metabolism -1.91 2.36e-3 32/49 (65.31%) LPCAT4;GAL3ST1;PLA2G12A;...
Collecting duct acid secretion -1.95 2.95e-3 22/27 (81.48%) ATP6V1A;ATP6V0D1;ATP6V0A4;...
Ferroptosis -2.06 3.93e-3 36/41 (87.8%) SLC39A8;ACSL1;SAT1;...
Steroid biosynthesis -2.13 0.00e+0 19/20 (95%) NSDHL;FDFT1;LIPA;...
Lysosome -2.14 0.00e+0 115/128 (89.84%) CTSF;FUCA1;CD63;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 90uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 90uM 6H, 24H, 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 90uM 6H
HT-29 CVCL_0320 Homo sapiens 90uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 90uM 6H
MDST8 CVCL_1400 Homo sapiens 90uM 6H
NCI-H508 CVCL_1561 Homo sapiens 90uM 6H
SNU-1040 CVCL_5001 Homo sapiens 90uM 6H
SNU-C4 CVCL_5008 Homo sapiens 90uM 6H
SW480 CVCL_0546 Homo sapiens 90uM 6H
SW620 CVCL_0547 Homo sapiens 90uM 6H
SW948 CVCL_0550 Homo sapiens 90uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 90uM 6H
HT115 CVCL_1294 Homo sapiens 90uM 6H
RKO CVCL_0504 Homo sapiens 90uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 90uM 6H
SNG-M CVCL_1707 Homo sapiens 90uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 90uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 90uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 90uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 90uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 90uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 90uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 90uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 90uM 6H
T3M-10 CVCL_1729 Homo sapiens 90uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 90uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 90uM 6H
HCC515 CVCL_5134 Homo sapiens 90uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 90uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 90uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 90uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 90uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 90uM 6H
OV7 CVCL_1623 Homo sapiens 90uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 90uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 90uM 6H
RMUG-S CVCL_1666 Homo sapiens 90uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 90uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 90uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 90uM 6H
PL-21 CVCL_2161 Homo sapiens 90uM 6H
SKM-1 CVCL_0010 Homo sapiens 90uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 90uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 90uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 90uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 90uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 90uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 90uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 90uM 6H