Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKL9QO)

Drug Name
Seocalcitol Drug Info
Synonyms
Seocalcitol; 134404-52-7; UNII-Q0OZ0D9223; EB-1089; Q0OZ0D9223; EB1089; EB 1089; Seocalcitol [INN:BAN]; CB-1089; (22E,24E)-1alpha,25-dihydroxy-26,27-dimethyl-22,23,24,24a-tetradehydro-24a-homovitamin D3 / (22E,24E)-1alpha,25-dihydroxy-26,27-dimethyl-22,23,24,24a-tetradehydro-24a-homocholecalciferol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3E,5E)-7-ethyl-7-hydroxynona-3,5-dien-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Cross-matching ID
PubChem CID
5288149
ChEBI ID
CHEMBL1908376
CAS Number
CAS 134404-52-7
TTD Drug ID
D09ZJQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 2.09 0.00e+0 86/96 (89.58%) TTN;TNNC1;MYL2;...
Hypertrophic cardiomyopathy 2.05 0.00e+0 81/90 (90%) TTN;TNNC1;MYL2;...
Pertussis 2.00 0.00e+0 64/76 (84.21%) MAPK13;TLR4;IL1B;...
Legionellosis 1.95 0.00e+0 51/57 (89.47%) EEF1A2;TLR4;IL1B;...
Cardiac muscle contraction 1.91 1.69e-3 64/87 (73.56%) TNNC1;MYL2;ACTC1;...
Fructose and mannose metabolism 1.86 4.22e-3 30/33 (90.91%) AKR1B1;FBP1;PFKFB3;...
Pentose phosphate pathway 1.83 8.44e-3 25/30 (83.33%) PGD;G6PD;FBP1;...
Galactose metabolism 1.81 9.50e-3 26/31 (83.87%) AKR1B1;HK2;GALE;...
Complement and coagulation cascades 1.80 1.22e-2 76/85 (89.41%) CFD;PLAT;ITGAM;...
Malaria 1.77 1.52e-2 44/50 (88%) TLR4;IL1B;IL6;...
Steroid biosynthesis 1.76 1.46e-2 19/20 (95%) NSDHL;DHCR7;DHCR24;...
Leishmaniasis 1.75 1.62e-2 67/77 (87.01%) MAPK13;EEF1A2;TLR4;...
Adrenergic signaling in cardiomyocytes 1.74 1.75e-2 130/150 (86.67%) MAPK13;TNNC1;MYL2;...
Calcium signaling pathway 1.70 3.07e-2 213/240 (88.75%) PDGFA;TNNC1;TNNC2;...
Amoebiasis 1.70 2.98e-2 99/102 (97.06%) TLR4;IL1B;FN1;...
Amino sugar and nucleotide sugar metabolism 1.67 3.75e-2 38/48 (79.17%) HK2;GALE;UAP1;...
Starch and sucrose metabolism 1.67 3.67e-2 25/36 (69.44%) PYGM;HK2;PYGL;...
Glycerophospholipid metabolism 1.63 4.83e-2 71/98 (72.45%) PLPP3;PLAAT3;GPD1L;...
Cell adhesion molecules -1.75 3.95e-2 118/148 (79.73%) HLA-G;ITGAL;PTPRF;...
Allograft rejection -1.81 2.25e-2 32/38 (84.21%) HLA-DPA1;CD40LG;HLA-DOB;...
Autoimmune thyroid disease -1.82 2.50e-2 46/53 (86.79%) HLA-G;TSHB;HLA-DPA1;...
Valine, leucine and isoleucine degradation -1.83 2.91e-2 42/48 (87.5%) DBT;HADHB;MCCC1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.97 6.24e-3 49/53 (92.45%) VDR;CLTB;ADCY6;...
Antigen processing and presentation -2.47 0.00e+0 60/78 (76.92%) PDIA3;HLA-G;CIITA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H