Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKLSHF)

• Drug Name: Bambuterol Drug Info
• Synonyms: Bambec; Bambuterolum; Oxeol; Bambuterolum [Latin]; Terbutaline bisdimethylcarbamate; Bambec (TN); Bambuterol (INN); Bambuterol [BAN:INN]; KWD-2183; Oxeol (TN); Terbutaline bis(dimethylcarbamate); [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate; (+-)-5-(2-(tert-Butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate); 5-(2-(tert-butylamino)-1-hydroxyethyl)-3-phenylene bis(dimethylcarbamate); 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate)
• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 54766
  ChEBI ID: CHEMBL521589
  CAS Number: CAS 81732-65-2
  TTD Drug ID: D07XYV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Dilated cardiomyopathy	1.96	4.50e-2	86/96 (89.58%)	TGFB1;GNAS;ACTC1;...
Hypertrophic cardiomyopathy	1.89	3.93e-2	81/90 (90%)	TGFB1;ACTC1;TNNC1;...
Retinol metabolism	-1.76	2.60e-2	41/68 (60.29%)	CYP1A1;UGT2A3;CYP2B6;...
NF-kappa B signaling pathway	-1.77	3.11e-2	90/104 (86.54%)	GADD45B;CXCL12;CCL21;...
Viral protein interaction with cytokine and cytokine re...	-1.77	3.46e-2	84/100 (84%)	CXCL12;IL6R;IL18R1;...
Linoleic acid metabolism	-1.83	2.88e-2	21/29 (72.41%)	CYP3A4;PLA2G12A;CYP2C8;...
Complement and coagulation cascades	-2.06	4.33e-3	76/85 (89.41%)	SERPIND1;FGA;CFHR5;...
Mineral absorption	-2.50	0.00e+0	48/60 (80%)	VDR;SLC30A1;MT1M;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼