Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKMCE1)

Drug Name
biotin Drug Info
Synonyms Biodermatin; Bioepiderm; Bios II; Biotin Forte; Factor S; Lutavit H2; Meribin; Rovimix H2
Cross-matching ID
PubChem CID
171548
ChEBI ID
CHEMBL857
CAS Number
CAS 58-85-5
TTD Drug ID
D0P8TJ
VARIDT Drug ID
DR00257

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral protein interaction with cytokine and cytokine re... 2.39 0.00e+0 84/100 (84%) CX3CR1;CCL20;CCL2;...
Staphylococcus aureus infection 2.26 0.00e+0 72/95 (75.79%) C1QA;CFB;C1R;...
IL-17 signaling pathway 2.22 0.00e+0 84/94 (89.36%) S100A8;S100A9;LCN2;...
Oxidative phosphorylation 2.04 2.29e-3 93/133 (69.92%) ATP6V1D;COX7B;ATP6V0E2;...
Cytokine-cytokine receptor interaction 2.00 3.67e-3 246/295 (83.39%) CX3CR1;CCL20;IL32;...
Citrate cycle (TCA cycle) 1.92 9.18e-3 30/30 (100%) DLD;SUCLA2;IDH2;...
Ribosome 1.89 1.05e-2 113/158 (71.52%) MRPL15;MRPL19;MRPS7;...
Graft-versus-host disease 1.85 1.15e-2 32/42 (76.19%) PRF1;GZMB;TNF;...
Rheumatoid arthritis 1.82 1.43e-2 78/93 (83.87%) CCL20;ATP6V1D;CCL2;...
DNA replication 1.81 1.56e-2 34/36 (94.44%) RFC3;POLE2;MCM6;...
Hematopoietic cell lineage 1.81 1.50e-2 90/99 (90.91%) CD2;IL7R;CD8A;...
NF-kappa B signaling pathway 1.81 1.45e-2 90/104 (86.54%) PRKCQ;CXCL8;LTB;...
Chemokine signaling pathway 1.78 1.48e-2 163/192 (84.9%) CX3CR1;CCL20;CCL2;...
Cytosolic DNA-sensing pathway 1.75 2.10e-2 52/63 (82.54%) CCL4;CCL5;POLR1D;...
Cell cycle 1.75 1.96e-2 110/124 (88.71%) MCM6;CCNB2;PTTG1;...
Proteasome 1.74 2.01e-2 44/46 (95.65%) POMP;PSMA3;SEM1;...
Primary immunodeficiency 1.69 2.48e-2 33/38 (86.84%) IL7R;CD8A;CD3E;...
Legionellosis 1.68 2.60e-2 51/57 (89.47%) CXCL8;CXCL1;ITGAM;...
Nucleotide excision repair 1.63 4.16e-2 40/47 (85.11%) RFC3;POLE2;MNAT1;...
Mismatch repair 1.63 4.13e-2 22/23 (95.65%) RFC3;PCNA;RFC4;...
Type I diabetes mellitus 1.62 4.42e-2 38/43 (88.37%) PRF1;GZMB;TNF;...
Chagas disease 1.62 4.34e-2 93/102 (91.18%) CCL2;C1QA;CXCL8;...
Pertussis 1.62 4.39e-2 64/76 (84.21%) C1QA;CXCL8;C1R;...
Systemic lupus erythematosus 1.59 4.93e-2 45/135 (33.33%) C1QA;C1R;C1S;...
T cell receptor signaling pathway 1.59 4.74e-2 93/104 (89.42%) PRKCQ;CD8A;CD247;...
Natural killer cell mediated cytotoxicity 1.59 4.55e-2 99/131 (75.57%) PRF1;GZMB;FCER1G;...
Thyroid hormone synthesis -1.84 3.48e-2 66/75 (88%) ADCY3;TTF2;TG;...
Steroid biosynthesis -1.93 7.14e-3 19/20 (95%) TM7SF2;SOAT1;EBP;...
Protein export -1.95 5.35e-3 17/23 (73.91%) SPCS3;OXA1L;SRP14;...
Protein processing in endoplasmic reticulum -2.01 1.07e-2 127/171 (74.27%) CAPN1;HSPA2;NFE2L2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H