Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKMWQG)

Drug Name
Olopatadine Drug Info
Synonyms
Allelock; Opatanol; Pataday; Patanase; Patanol; OLOPATADINE HCl; OLOPATADINE HYDROCHLORIDE; ALO4943A; HCl of KW 4679; KW 4679; O0361; AL-4943A; ALO-4943A; Allelock (TN); KW-4679; KW-4943A; Olopatadine [INN:BAN]; Pataday (TN); Patanase (TN); Patanol S (TN); {(11Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid hydrochloride; 11-((Z)-3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid, hydrochloride; 11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin-2-acetic acid; 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid; 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid hydrochloride
Therapeutic ClassAntiallergic Agents
Cross-matching ID
PubChem CID
5281071
ChEBI ID
CHEMBL94593
CAS Number
CAS 113806-05-6
TTD Drug ID
D05GPO
VARIDT Drug ID
DR01357
INTEDE Drug ID
DR1192

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nitrogen metabolism 1.87 2.74e-2 16/17 (94.12%) CA2;CA12;GLUD1;...
Protein digestion and absorption 1.82 2.74e-2 78/103 (75.73%) COL9A3;COL4A5;DPP4;...
Hematopoietic cell lineage -1.69 4.81e-2 90/99 (90.91%) CD4;CD59;CSF2;...
Thermogenesis -1.71 4.51e-2 173/232 (74.57%) COX6C;ATP5PB;NDUFA9;...
RNA degradation -1.72 4.69e-2 53/79 (67.09%) CNOT7;LSM7;CNOT3;...
Prion disease -1.81 1.46e-2 209/273 (76.56%) FYN;COX6C;ITPR3;...
Fructose and mannose metabolism -1.81 1.75e-2 30/33 (90.91%) TPI1;GMPPA;AKR1B10;...
Viral protein interaction with cytokine and cytokine re... -1.82 2.19e-2 84/100 (84%) CSF1;CXCR2;TNFRSF14;...
Mismatch repair -1.84 2.55e-2 22/23 (95.65%) POLD4;MLH1;MSH3;...
Diabetic cardiomyopathy -1.85 3.83e-2 162/203 (79.8%) COX6C;ATP5PB;NDUFA9;...
Oxidative phosphorylation -2.17 0.00e+0 93/133 (69.92%) COX6C;ATP5PB;NDUFA9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H