Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKNQW4)

Drug Name
7,8-dichloroquinoline-4-one-3-carboxylic acid Drug Info
Synonyms
300675-28-9; 7,8-DICHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID; 144061-33-6; 7,8-dichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 7,8-dichloro-4-oxo-1H-quinoline-3-carboxylic Acid; CHEMBL218566; 7,8-Dichloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; J-650168; 7,8-dichloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; AC1LEVOV; Oprea1_635608; Oprea1_583373; SCHEMBL9654331; SCHEMBL17502115; CTK7I6370; CHEBI:94582; DTXSID00351180; MolPort-000-680-344; MolPort-000-651-074; ZINC3945161; STK539875; MFCD01909987
Cross-matching ID
PubChem CID
693139
ChEBI ID
CHEMBL218566
CAS Number
CAS 144061-33-6
TTD Drug ID
D0V5HG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Citrate cycle (TCA cycle) 2.18 0.00e+0 30/30 (100%) DLD;ACO2;SUCLG1;...
Cell cycle 2.12 0.00e+0 110/124 (88.71%) PCNA;CDC20;CDK6;...
DNA replication 2.00 0.00e+0 34/36 (94.44%) PCNA;MCM2;MCM5;...
Base excision repair 1.91 9.23e-3 29/33 (87.88%) PCNA;FEN1;LIG1;...
Diabetic cardiomyopathy 1.85 1.72e-2 162/203 (79.8%) MMP9;COL3A1;COX5A;...
Viral carcinogenesis 1.77 4.72e-2 149/203 (73.4%) CDC20;CDK6;SKP2;...
Pertussis -1.64 4.39e-2 64/76 (84.21%) CALML5;GNAI3;CASP1;...
Glycerolipid metabolism -1.64 4.58e-2 44/61 (72.13%) MGLL;DGKD;AGPAT1;...
Phenylalanine metabolism -1.64 4.90e-2 14/17 (82.35%) AOC2;TAT;ALDH3B1;...
Glycerophospholipid metabolism -1.66 4.29e-2 71/98 (72.45%) PEMT;GPD2;DGKD;...
Pantothenate and CoA biosynthesis -1.70 3.50e-2 14/21 (66.67%) ENPP1;BCAT1;ALDH2;...
Linoleic acid metabolism -1.70 3.45e-2 21/29 (72.41%) CYP2C8;PLA2G4A;CYP2E1;...
Steroid hormone biosynthesis -1.72 3.23e-2 43/61 (70.49%) HSD17B12;CYP3A7;CYP11B2;...
alpha-Linolenic acid metabolism -1.75 2.06e-2 17/25 (68%) PLA2G4A;FADS2;PLA2G12A;...
Retinol metabolism -1.80 1.41e-2 41/68 (60.29%) CYP2C8;ADH1A;RDH11;...
Pentose and glucuronate interconversions -1.83 9.23e-3 17/34 (50%) UGT2B4;KL;UGDH;...
Metabolism of xenobiotics by cytochrome P450 -1.85 9.42e-3 49/77 (63.64%) ALDH3B1;ADH1A;GSTA1;...
Protein processing in endoplasmic reticulum -1.88 9.69e-3 127/171 (74.27%) RBX1;SEC24D;HSPA1L;...
beta-Alanine metabolism -1.88 1.21e-2 25/30 (83.33%) CNDP2;DPYS;ALDH3B1;...
Steroid biosynthesis -1.90 1.35e-2 19/20 (95%) LIPA;TM7SF2;CYP51A1;...
Complement and coagulation cascades -1.93 1.61e-2 76/85 (89.41%) ITGAX;CFHR2;SERPINE1;...
Ascorbate and aldarate metabolism -2.22 0.00e+0 15/30 (50%) UGT2B4;KL;ALDH7A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H