General Information of Drug (ID: DMKNUYF)

Drug Name
CMPD1 Drug Info
Synonyms MAPKAPK2a inhibitor
Cross-matching ID
PubChem CID
11382492
ChEBI ID
CHEMBL235658
CAS Number
CAS 41179-33-3
TTD Drug ID
D0O7UT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.43 0.00e+0 103/112 (91.96%) CXCL3;CXCL2;CCL20;...
IL-17 signaling pathway 2.39 0.00e+0 84/94 (89.36%) CXCL8;CXCL3;FOSL1;...
Viral protein interaction with cytokine and cytokine re... 2.19 0.00e+0 84/100 (84%) CXCL8;CXCL3;TNFRSF10B;...
Prostate cancer 2.16 0.00e+0 93/97 (95.88%) PDGFA;CDKN1A;PIK3CD;...
Rheumatoid arthritis 2.13 2.88e-3 78/93 (83.87%) CXCL8;CXCL3;VEGFA;...
Epithelial cell signaling in Helicobacter pylori infect... 2.09 2.40e-3 62/70 (88.57%) CXCL8;PAK1;CXCL3;...
C-type lectin receptor signaling pathway 2.07 4.12e-3 93/104 (89.42%) PAK1;NFATC3;RELB;...
Lipid and atherosclerosis 2.01 3.60e-3 190/215 (88.37%) CXCL8;NFATC3;CXCL3;...
NF-kappa B signaling pathway 1.99 3.20e-3 90/104 (86.54%) CXCL8;RELB;CXCL3;...
Mineral absorption 1.99 2.88e-3 48/60 (80%) HMOX1;STEAP1;MT1X;...
Kaposi sarcoma-associated herpesvirus infection 1.97 3.93e-3 172/193 (89.12%) CXCL8;NFATC3;CXCL3;...
AGE-RAGE signaling pathway in diabetic complications 1.97 3.60e-3 97/100 (97%) CXCL8;VEGFA;PIK3CD;...
T cell receptor signaling pathway 1.94 4.44e-3 93/104 (89.42%) PAK1;NFATC3;PIK3CD;...
NOD-like receptor signaling pathway 1.90 4.12e-3 145/181 (80.11%) CXCL8;CXCL3;CXCL2;...
Natural killer cell mediated cytotoxicity 1.89 5.77e-3 99/131 (75.57%) PAK1;TNFRSF10B;PIK3CD;...
Thyroid cancer 1.86 8.11e-3 36/37 (97.3%) CDKN1A;MYC;GADD45A;...
Bladder cancer 1.86 9.33e-3 40/41 (97.56%) CXCL8;VEGFA;HBEGF;...
Focal adhesion 1.85 8.81e-3 180/201 (89.55%) PAK1;LAMC2;VEGFA;...
Cytokine-cytokine receptor interaction 1.82 1.06e-2 246/295 (83.39%) CXCL8;CXCL3;TNFRSF10B;...
HIF-1 signaling pathway 1.81 1.08e-2 105/109 (96.33%) HMOX1;VEGFA;CDKN1A;...
Legionellosis 1.80 1.17e-2 51/57 (89.47%) CXCL8;CXCL3;ITGAM;...
Protein processing in endoplasmic reticulum 1.80 1.11e-2 127/171 (74.27%) HERPUD1;HSPA6;DDIT3;...
MAPK signaling pathway 1.80 1.07e-2 272/294 (92.52%) PAK1;NFATC3;RELB;...
Leukocyte transendothelial migration 1.78 1.50e-2 90/114 (78.95%) ITGAM;PIK3CD;ACTN1;...
Fluid shear stress and atherosclerosis 1.77 1.61e-2 123/139 (88.49%) HMOX1;VEGFA;PDGFA;...
Ferroptosis 1.77 1.61e-2 36/41 (87.8%) HMOX1;SLC39A14;MAP1LC3B;...
PI3K-Akt signaling pathway 1.75 1.87e-2 317/354 (89.55%) LAMC2;VEGFA;PDGFA;...
Salmonella infection 1.74 1.96e-2 198/249 (79.52%) CXCL8;PAK1;TNFRSF10B;...
ErbB signaling pathway 1.72 2.49e-2 79/85 (92.94%) PAK1;HBEGF;CDKN1A;...
Collecting duct acid secretion 1.72 2.47e-2 22/27 (81.48%) CA2;SLC4A1;ATP6V1D;...
Retinol metabolism -1.73 2.83e-2 41/68 (60.29%) ADH7;DHRS9;CYP3A7;...
Ascorbate and aldarate metabolism -1.77 2.11e-2 15/30 (50%) UGT2A3;ALDH1B1;UGT2B28;...
Pentose and glucuronate interconversions -1.82 1.42e-2 17/34 (50%) AKR1B1;UGT2A3;RPE;...
Sulfur metabolism -1.84 1.25e-2 9/10 (90%) TST;PAPSS1;SELENBP1;...
Pyruvate metabolism -1.94 2.83e-3 41/47 (87.23%) FH;ME1;ACYP2;...
Complement and coagulation cascades -1.95 3.78e-3 76/85 (89.41%) C1QA;C8B;C7;...
Drug metabolism -2.05 2.83e-3 78/151 (51.66%) ADH7;FMO4;GSTA1;...
Metabolism of xenobiotics by cytochrome P450 -2.34 0.00e+0 49/77 (63.64%) CYP2F1;GSTM2;UGT2A3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H