Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKRBL2)

Drug Name
Bisbenzimide (Hoechst 33258) Drug Info
Synonyms
Hoechst 33342; 23491-52-3; Bisbenzimide; hoechst33342; UNII-99KZS6CNZX; Ho 342; 2'-(4-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole; EINECS 245-691-1; 99KZS6CNZX; 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole; CHEMBL343002; CHEBI:51232; 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole; 2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazole trihydrochloride trihydrate
Cross-matching ID
PubChem CID
1464
ChEBI ID
CHEMBL51232
CAS Number
CAS 23491-52-3
TTD Drug ID
D0G2JZ
VARIDT Drug ID
DR01292

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.24 0.00e+0 76/85 (89.41%) CFB;C3;F2R;...
Glyoxylate and dicarboxylate metabolism 2.00 0.00e+0 23/30 (76.67%) ACAT1;GLDC;MDH2;...
Antigen processing and presentation 1.98 0.00e+0 60/78 (76.92%) HLA-DQA1;TAP2;HLA-DOB;...
Glycolysis / Gluconeogenesis 1.82 4.53e-2 56/67 (83.58%) PGAM1;PFKM;ADPGK;...
Basal cell carcinoma 1.80 4.14e-2 41/63 (65.08%) LEF1;GADD45B;CTNNB1;...
Lysosome 1.79 3.67e-2 115/128 (89.84%) GNPTAB;PLA2G15;SLC11A2;...
Butanoate metabolism 1.77 4.62e-2 23/28 (82.14%) HMGCS2;ACAT1;ABAT;...
Primary immunodeficiency 1.77 4.05e-2 33/38 (86.84%) TAP2;ZAP70;IL7R;...
Citrate cycle (TCA cycle) 1.77 3.60e-2 30/30 (100%) IDH1;OGDHL;MDH2;...
Biosynthesis of unsaturated fatty acids 1.77 3.50e-2 21/27 (77.78%) ACAA1;SCD5;HACD3;...
Phagosome 1.76 3.30e-2 118/152 (77.63%) TFRC;THBS2;C3;...
Glycine, serine and threonine metabolism 1.73 4.10e-2 31/40 (77.5%) PGAM1;SDS;ALAS2;...
Taurine and hypotaurine metabolism 1.71 4.78e-2 8/11 (72.73%) ADO;GGT1;GAD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H