General Information of Drug (ID: DMKSFL0)

Drug Name
SB-242235 Drug Info
Synonyms
193746-75-7; SB-242235; SB242235; SB 242235; 4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine; CHEMBL95692; 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine; Kinome_3169; SCHEMBL2267209; BDBM15458; SYN1076; PDTYLGXVBIWRIM-UHFFFAOYSA-N; MolPort-028-720-427; HMS3244I18; HMS3244J17; HMS3244I17; EX-A1881; BCP05992; ZINC1487129; 3254AH; RS0056; AKOS027323444; CS-2097; NCGC00345831-01; NCGC00345831-03
Cross-matching ID
PubChem CID
9863367
ChEBI ID
CHEMBL95692
TTD Drug ID
D0A9KI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 2.28 0.00e+0 86/96 (89.58%) TTN;ADCY1;ATP2A2;...
Hypertrophic cardiomyopathy 2.02 4.79e-3 81/90 (90%) TTN;ATP2A2;TNNC1;...
Regulation of lipolysis in adipocytes 1.96 1.28e-2 52/55 (94.55%) GNAI1;ADCY1;IRS1;...
GABAergic synapse 1.93 9.58e-3 76/89 (85.39%) GNAI1;ADCY1;PRKCA;...
Gastric acid secretion 1.85 1.92e-2 63/76 (82.89%) GNAI1;ADCY1;PRKCA;...
Adrenergic signaling in cardiomyocytes 1.85 2.24e-2 130/150 (86.67%) GNAI1;ADCY1;ATP2A2;...
Neomycin, kanamycin and gentamicin biosynthesis 1.82 2.19e-2 5/5 (100%) HK2;HK3
Morphine addiction 1.81 2.16e-2 80/91 (87.91%) GNAI1;ADCY1;PRKCA;...
Central carbon metabolism in cancer 1.80 2.02e-2 67/70 (95.71%) SIRT3;RET;HK2;...
Rap1 signaling pathway 1.75 2.97e-2 184/210 (87.62%) GNAI1;ADCY1;LPAR1;...
ECM-receptor interaction 1.75 2.79e-2 80/88 (90.91%) COL4A6;COL6A1;LAMA2;...
Protein digestion and absorption 1.75 2.72e-2 78/103 (75.73%) COL4A6;COL6A1;ATP1A2;...
Relaxin signaling pathway 1.74 2.80e-2 114/129 (88.37%) GNAI1;ADCY1;COL4A6;...
Melanogenesis 1.73 2.81e-2 74/101 (73.27%) GNAI1;ADCY1;PRKCA;...
Proteoglycans in cancer 1.72 2.94e-2 172/205 (83.9%) ANK2;PRKCA;COL1A2;...
Focal adhesion 1.70 3.89e-2 180/201 (89.55%) COL4A6;COL6A1;PRKCA;...
Viral protein interaction with cytokine and cytokine re... -1.71 2.07e-2 84/100 (84%) CXCL5;CCL20;CXCL1;...
Phagosome -1.73 1.74e-2 118/152 (77.63%) FCGR3B;SEC61G;MSR1;...
Protein processing in endoplasmic reticulum -1.74 1.65e-2 127/171 (74.27%) EIF2S1;SEC24B;SAR1A;...
NOD-like receptor signaling pathway -1.76 1.36e-2 145/181 (80.11%) GABARAPL2;DEFA6;HSP90AA1;...
Metabolism of xenobiotics by cytochrome P450 -1.79 1.21e-2 49/77 (63.64%) CYP1B1;UGT2B15;CYP3A5;...
Protein export -1.80 1.13e-2 17/23 (73.91%) SEC11A;SEC61G;SRPRA;...
Primary bile acid biosynthesis -1.81 1.14e-2 15/17 (88.24%) ACOX2;SLC27A5;CYP7B1;...
TNF signaling pathway -1.83 9.59e-3 103/112 (91.96%) DNM1L;CHUK;BIRC2;...
Amyotrophic lateral sclerosis -1.84 9.55e-3 267/364 (73.35%) NDUFA10;SDHC;NDUFA4L2;...
Coronavirus disease -1.84 1.00e-2 215/232 (92.67%) RPS10;PLCG2;RPL41;...
Kaposi sarcoma-associated herpesvirus infection -1.84 1.05e-2 172/193 (89.12%) IFNA16;IFNA5;AKT2;...
Alzheimer disease -1.84 1.05e-2 279/369 (75.61%) APH1B;CSNK2A2;RTN4;...
Autoimmune thyroid disease -1.86 9.34e-3 46/53 (86.79%) HLA-E;HLA-DQA1;HLA-A;...
Type I diabetes mellitus -1.90 6.80e-3 38/43 (88.37%) HLA-G;CD28;IL1B;...
Ascorbate and aldarate metabolism -1.94 6.57e-3 15/30 (50%) AKR1A1;KL;UGT2B15;...
Allograft rejection -1.95 7.00e-3 32/38 (84.21%) HLA-E;HLA-DQA1;HLA-A;...
Prion disease -2.01 4.50e-3 209/273 (76.56%) CSNK2A2;NDUFA10;SDHC;...
Non-alcoholic fatty liver disease -2.03 3.23e-3 126/155 (81.29%) NDUFA10;SDHC;AKT2;...
Retinol metabolism -2.06 1.75e-3 41/68 (60.29%) RDH16;CYP2W1;RETSAT;...
Graft-versus-host disease -2.09 9.55e-4 32/42 (76.19%) KLRD1;HLA-G;CD28;...
Antigen processing and presentation -2.10 1.05e-3 60/78 (76.92%) KLRC3;NFYA;TAPBP;...
Epithelial cell signaling in Helicobacter pylori infect... -2.15 1.17e-3 62/70 (88.57%) HBEGF;LYN;CDC42;...
Huntington disease -2.17 1.31e-3 233/306 (76.14%) NDUFA10;SDHC;NDUFA4L2;...
Proteasome -2.20 1.50e-3 44/46 (95.65%) SEM1;PSMB4;PSMB1;...
Rheumatoid arthritis -2.27 0.00e+0 78/93 (83.87%) JUN;CD28;IL1B;...
Legionellosis -2.29 0.00e+0 51/57 (89.47%) C3;HBS1L;HSPA2;...
Parkinson disease -2.29 0.00e+0 176/249 (70.68%) TH;NDUFA10;SDHC;...
IL-17 signaling pathway -2.41 0.00e+0 84/94 (89.36%) RELA;MMP9;CXCL6;...
Ribosome -2.46 0.00e+0 113/158 (71.52%) RPS3A;MRPL11;MRPL16;...
Oxidative phosphorylation -2.69 0.00e+0 93/133 (69.92%) ATP6V1B2;COX11;NDUFA10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H