Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKVF5Q)

Drug Name
TCPOBOP Drug Info
Synonyms
tcpobop; 76150-91-9; 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene; 1,4-BDPOB; CCRIS 3521; 2,2'-[1,4-phenylenebis(oxy)]bis(3,5-dichloropyridine); 1,4-Bis(2-(3,5-dichloropyridyloxy))benzene; 3,5-DICHLORO-2-{4-[(3,5-DICHLOROPYRIDIN-2-YL)OXY]PHENOXY}PYRIDINE; MLS000532100; 2,2'-[benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine); 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene; 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene; Pyridine,2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro-
Cross-matching ID
PubChem CID
5382
ChEBI ID
CHEMBL488803
CAS Number
CAS 76150-91-9
TTD Drug ID
D02BPI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mismatch repair 1.89 3.57e-2 22/23 (95.65%) PCNA;MSH2;RFC5;...
DNA replication 1.86 2.50e-2 34/36 (94.44%) PCNA;MCM4;MCM5;...
Fanconi anemia pathway 1.85 1.91e-2 36/54 (66.67%) FANCG;FANCI;FANCL;...
Terpenoid backbone biosynthesis 1.79 3.22e-2 18/22 (81.82%) ACAT2;HMGCS2;IDI1;...
Alanine, aspartate and glutamate metabolism -1.72 4.51e-2 27/37 (72.97%) GFPT1;CPS1;GAD1;...
Proteasome -1.72 4.84e-2 44/46 (95.65%) PSMD11;PSMB5;PSMB8;...
Mitophagy -1.74 4.03e-2 56/68 (82.35%) USP8;CSNK2A2;ATG5;...
Complement and coagulation cascades -1.74 4.53e-2 76/85 (89.41%) CFB;THBD;C3;...
Phenylalanine metabolism -1.79 3.45e-2 14/17 (82.35%) TAT;AOC2;AOC3;...
Ferroptosis -1.81 3.02e-2 36/41 (87.8%) CP;PCBP2;PCBP1;...
Phagosome -1.81 3.63e-2 118/152 (77.63%) C3;SCARB1;STX18;...
Staphylococcus aureus infection -1.97 3.02e-3 72/95 (75.79%) CFB;C3;PTAFR;...
Pertussis -2.00 0.00e+0 64/76 (84.21%) C5;C2;IL23A;...
Protein processing in endoplasmic reticulum -2.00 0.00e+0 127/171 (74.27%) FBXO2;HSPA5;SEC24A;...
Mineral absorption -2.27 0.00e+0 48/60 (80%) TRPV6;ATP1B1;FTH1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H