Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKVOYF)

• Drug Name: Penicillin V Drug Info
• Synonyms: Apocillin; Apopen; Beromycin; Calcipen; Fenacilin; Fenospen; Fenossimetilpenicillina; Fenoximetilpenicilina; Fenoxymethylpenicillin; Fenoxypen; Meropenin; Oracillin; Oratren; Ospen; PNV; PVA; Phenocillin; Phenomycilline; Phenopenicillin; Phenoximethylpenicillinum; Phenoxomethylpenicillanyl; Phenoxomethylpenicillin; Phenoxymethylpenicillanyl; Phenoxymethylpenicillin; Phenoxymethylpenicilline; Phenoxymethylpenicillinum; Robicillin; Rocilin; Stabicillin; Vebecillin; Vegacillin; Acipen V; Compocillin V; Crystapen V; Distaquaine V; Eskacillian V; Eskacillin V; Fenossimetilpenicillina [DCIT]; Penicillin V [USAN]; Penicillin phenoxymethyl; Phenoxymethyl penicillin; Phenoxymethylenepenicillinic acid; Phenoxymethylpenicillinic acid; Phenoxymethylpenicillinic acid potassium salt; Acipen-v; Beromycin, Penicillin; Berromycin, Penicillin; Fenoximetilpenicilina [INN-Spanish]; Pen-Oral; Pen-V; Pen-vee; Penicillin V (USP); Penicillin, Phenoxymethyl; Phenoxymethylpenicillin (INN); Phenoxymethylpenicilline [INN-French]; Phenoxymethylpenicillinum [INN-Latin]; V-Cil; V-Cillin; V-Cylina; V-Cyline; V-Tablopen; P-Mega-Tablinen; V-Cillin (TN); (2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-(2-PHENOXYACETAMIDO)-4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(phenyloxy)acetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 2,2-dimethyl-6beta-[(phenoxyacetyl)amino]penam-3alpha-carbonyl; 2,2-dimethyl-6beta-[(phenoxyacetyl)amino]penam-3alpha-carboxylic acid; 3,3-Dimethyl-7-oxo-6-((phenyloxyacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 3,3-dimethyl-6beta-[(phenoxyacetyl)amino]penam-2alpha-carboxylic acid (PIN); 6-Phenoxyacetamidopenicillanic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6869
  ChEBI ID: CHEMBL27446
  CAS Number: CAS 87-08-1
  TTD Drug ID: D09CPR
  VARIDT Drug ID: DR00868
  ACDINA Drug ID: D00515

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.80	4.92e-2	34/36 (94.44%)	POLE2;MCM6;POLA1;...
Natural killer cell mediated cytotoxicity	-1.74	2.11e-2	99/131 (75.57%)	CSF2;IFNAR1;RAC1;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.75	2.01e-2	62/70 (88.57%)	TCIRG1;CXCR2;IKBKB;...
Hematopoietic cell lineage	-1.75	2.09e-2	90/99 (90.91%)	ITGA4;GP1BA;IL1B;...
Chemokine signaling pathway	-1.75	2.16e-2	163/192 (84.9%)	GNG5;GRK6;ADCY8;...
Phagosome	-1.76	1.92e-2	118/152 (77.63%)	ATP6V0E2;OLR1;ITGB1;...
Lipid and atherosclerosis	-1.76	1.99e-2	190/215 (88.37%)	MAP3K5;MAP2K3;FAS;...
Apelin signaling pathway	-1.78	1.66e-2	117/137 (85.4%)	MRAS;GNAI2;GNAI3;...
Graft-versus-host disease	-1.78	1.73e-2	32/42 (76.19%)	GZMB;IL1A;TNF;...
Shigellosis	-1.79	1.81e-2	180/246 (73.17%)	TLR5;MYL12B;ITPR1;...
Metabolism of xenobiotics by cytochrome P450	-1.82	1.08e-2	49/77 (63.64%)	CYP2A6;HPGDS;ADH6;...
Neutrophil extracellular trap formation	-1.85	8.54e-3	101/189 (53.44%)	CLCN3;PLCB2;PIK3CA;...
Antigen processing and presentation	-1.85	8.99e-3	60/78 (76.92%)	KLRD1;KIR2DS4;HLA-DPB1;...
Inflammatory bowel disease	-1.85	7.12e-3	58/65 (89.23%)	SMAD2;IL4R;HLA-DPB1;...
Amoebiasis	-1.87	6.70e-3	99/102 (97.06%)	RAB5C;CD1E;PLCB2;...
Carbohydrate digestion and absorption	-1.88	7.12e-3	37/47 (78.72%)	LCT;SLC2A5;PLCB4;...
Type I diabetes mellitus	-1.88	7.59e-3	38/43 (88.37%)	HLA-DPB1;HLA-G;IL1B;...
Rheumatoid arthritis	-1.90	7.12e-3	78/93 (83.87%)	IFNG;LTB;VEGFA;...
Human immunodeficiency virus 1 infection	-1.90	6.57e-3	189/212 (89.15%)	MAP2K3;GNAI2;GNAI3;...
Human cytomegalovirus infection	-1.93	4.75e-3	201/225 (89.33%)	IL10RB;NFKB1;PTGS2;...
Steroid biosynthesis	-1.97	3.88e-3	19/20 (95%)	SC5D;FDFT1;HSD17B7;...
TNF signaling pathway	-2.00	1.42e-3	103/112 (91.96%)	NFKB1;PTGS2;IL1B;...
Ferroptosis	-2.00	1.58e-3	36/41 (87.8%)	FTL;PRNP;PCBP1;...
Th1 and Th2 cell differentiation	-2.01	1.78e-3	80/92 (86.96%)	RUNX3;IL2RB;PLCG1;...
Kaposi sarcoma-associated herpesvirus infection	-2.01	2.03e-3	172/193 (89.12%)	PLCG1;JAK2;NFKB1;...
Th17 cell differentiation	-2.02	0.00e+0	95/107 (88.79%)	IL21R;IL2RB;PLCG1;...
GnRH secretion	-2.03	0.00e+0	60/64 (93.75%)	ITPR1;PLCB4;CACNA1I;...
NF-kappa B signaling pathway	-2.06	0.00e+0	90/104 (86.54%)	BIRC3;PLCG1;ZAP70;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	-2.07	0.00e+0	79/89 (88.76%)	PLCG1;JAK2;ZAP70;...
Lysosome	-2.09	0.00e+0	115/128 (89.84%)	ARSB;TPP1;GM2A;...
IL-17 signaling pathway	-2.19	0.00e+0	84/94 (89.36%)	IKBKB;S100A9;FOS;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.66uM - 20uM	3H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼