Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKXPCR)

• Drug Name: Pyrvinium Drug Info
• Synonyms: Povan
• Cross-matching ID:
  PubChem CID: 5281035
  ChEBI ID: CHEMBL1201303
  CAS Number: CAS 7187-62-4
  TTD Drug ID: D0A0SP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Sulfur metabolism	2.00	0.00e+0	9/10 (90%)	TST;ETHE1;MPST;...
Lysosome	1.90	1.22e-2	115/128 (89.84%)	TPP1;GUSB;CTSL;...
Protein digestion and absorption	1.89	8.15e-3	78/103 (75.73%)	SLC3A2;CPA3;ELN;...
Mitophagy	1.82	3.36e-2	56/68 (82.35%)	ATF4;GABARAPL1;SQSTM1;...
Proteasome	-1.60	4.49e-2	44/46 (95.65%)	PSMB10;PSMB1;PSMC6;...
Fatty acid degradation	-1.65	3.19e-2	40/43 (93.02%)	GCDH;ALDH9A1;ALDH1B1;...
Pyrimidine metabolism	-1.66	3.12e-2	40/56 (71.43%)	CTPS1;DCTPP1;CTPS2;...
Base excision repair	-1.69	2.75e-2	29/33 (87.88%)	SMUG1;POLE3;PARP1;...
Nucleotide excision repair	-1.77	1.13e-2	40/47 (85.11%)	ERCC1;RFC2;POLD3;...
Non-homologous end-joining	-1.78	1.17e-2	11/13 (84.62%)	PRKDC;DCLRE1C;DNTT;...
Aminoacyl-tRNA biosynthesis	-1.79	1.15e-2	15/66 (22.73%)	FARS2;GATC;HARS2;...
Spliceosome	-1.89	3.44e-3	101/150 (67.33%)	SF3A1;SNU13;SRSF10;...
Homologous recombination	-1.95	9.82e-4	35/41 (85.37%)	POLD3;BRCA2;RAD51C;...
Progesterone-mediated oocyte maturation	-1.96	1.15e-3	75/100 (75%)	PGR;PIK3CD;HSP90AA1;...
Cell cycle	-2.00	0.00e+0	110/124 (88.71%)	SKP2;RBL1;CCNE2;...
Fanconi anemia pathway	-2.15	0.00e+0	36/54 (66.67%)	ERCC1;TELO2;MLH1;...
Oocyte meiosis	-2.16	0.00e+0	90/129 (69.77%)	CDC23;ITPR1;ADCY9;...
Mismatch repair	-2.25	0.00e+0	22/23 (95.65%)	RFC2;MLH1;POLD3;...
DNA replication	-2.57	0.00e+0	34/36 (94.44%)	POLE3;SSBP1;RPA3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲