Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKY1L4)

• Drug Name: Glucose-6-Phosphate Drug Info
• Synonyms: Robison ester; Glucose 6-phosphate; 6-O-phosphono-D-glucopyranose; D-glucopyranose 6-phosphate; D-glucopyranose, 6-(dihydrogen phosphate); Glucose 6-(dihydrogen phosphate); 299-31-0; {[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid; D-glucose-6P; Glc6P; D-glucose-6-P; a-D-glucose 6- phosphate; AC1L1LI0; SCHEMBL48379; CHEBI:4170; GTPL4647; AC1Q28E3; D-Glucopyranose 6-phosphoric acid
• Cross-matching ID:
  PubChem CID: 5958
  ChEBI ID: CHEMBL4170
  CAS Number: CAS 299-31-0
  TTD Drug ID: D05TIS
  VARIDT Drug ID: DR00098

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Allograft rejection	1.98	1.59e-2	32/38 (84.21%)	HLA-DOB;CD40;HLA-DQB1;...
Autoimmune thyroid disease	1.95	7.94e-3	46/53 (86.79%)	HLA-DOB;CD40;CGA;...
Staphylococcus aureus infection	1.94	5.29e-3	72/95 (75.79%)	KRT17;KRT10;KRT23;...
Graft-versus-host disease	1.90	5.95e-3	32/42 (76.19%)	HLA-DOB;HLA-DQB1;GZMB;...
Type I diabetes mellitus	1.90	4.76e-3	38/43 (88.37%)	HLA-DOB;GAD1;HLA-DQB1;...
Asthma	1.85	7.94e-3	25/31 (80.65%)	HLA-DOB;CD40;PRG2;...
Viral myocarditis	1.84	1.02e-2	53/60 (88.33%)	HLA-DOB;CD40;CASP8;...
Phototransduction	1.78	1.19e-2	21/29 (72.41%)	CALML3;CALML4;CALML5;...
Renin-angiotensin system	1.70	3.09e-2	20/23 (86.96%)	CPA3;CTSG;KLK2;...
One carbon pool by folate	-1.71	4.42e-2	15/20 (75%)	GART;MTHFD2;AMT;...
Salivary secretion	-1.71	4.51e-2	76/93 (81.72%)	MUC5B;PRKG1;ATP1B3;...
Alanine, aspartate and glutamate metabolism	-1.83	1.32e-2	27/37 (72.97%)	ALDH4A1;GLUL;ADSL;...
Terpenoid backbone biosynthesis	-1.84	1.33e-2	18/22 (81.82%)	HMGCR;GGPS1;FDPS;...
Amino sugar and nucleotide sugar metabolism	-1.85	1.36e-2	38/48 (79.17%)	CYB5R3;HK1;HEXA;...
Citrate cycle (TCA cycle)	-1.87	1.38e-2	30/30 (100%)	IDH3G;ACO2;PDHA1;...
Pentose phosphate pathway	-1.91	1.19e-2	25/30 (83.33%)	GPI;RPIA;TKT;...
Valine, leucine and isoleucine degradation	-1.94	1.19e-2	42/48 (87.5%)	BCAT2;PCCB;HMGCL;...
Glycolysis / Gluconeogenesis	-1.97	7.91e-3	56/67 (83.58%)	PGK1;ALDH3A2;ALDH9A1;...
Fructose and mannose metabolism	-2.04	0.00e+0	30/33 (90.91%)	PFKM;PFKFB2;HK3;...
Galactose metabolism	-2.07	0.00e+0	26/31 (83.87%)	PFKM;GAA;GLB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲