Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMKYXJW)

Drug Name
Dorsomorphin Drug Info
Synonyms
dorsomorphin; 866405-64-3; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; BML-275; Compound C; AMPK Inhibitor, Compound C; 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; CHEMBL478629; CHEBI:78510; 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine; 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine; AMPK Inhibitor
Cross-matching ID
PubChem CID
11524144
ChEBI ID
CHEMBL478629
CAS Number
CAS 866405-64-3
TTD Drug ID
D0Y0BK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Phagosome 2.31 0.00e+0 118/152 (77.63%) THBS1;TFRC;TUBB2A;...
Biosynthesis of unsaturated fatty acids 2.20 0.00e+0 21/27 (77.78%) ACOT7;ELOVL5;SCD;...
Complement and coagulation cascades 2.09 0.00e+0 76/85 (89.41%) SERPINA1;CLU;CD59;...
Steroid biosynthesis 1.99 6.71e-3 19/20 (95%) MSMO1;DHCR24;CYP51A1;...
Glycine, serine and threonine metabolism 1.93 5.36e-3 31/40 (77.5%) PSAT1;MAOA;MAOB;...
Cholesterol metabolism 1.92 4.47e-3 44/50 (88%) LDLR;APOA1;APOB;...
Arginine biosynthesis 1.92 3.83e-3 17/22 (77.27%) GLUD2;GLUD1;ARG2;...
Malaria 1.91 3.35e-3 44/50 (88%) THBS1;SDC2;ACKR1;...
Nitrogen metabolism 1.88 5.96e-3 16/17 (94.12%) CA2;GLUD2;GLUD1;...
Collecting duct acid secretion 1.87 5.36e-3 22/27 (81.48%) CA2;ATP6V1G1;ATP6V0C;...
Fatty acid elongation 1.85 4.88e-3 19/27 (70.37%) ACOT7;ELOVL5;HACD3;...
Oxidative phosphorylation 1.82 8.94e-3 93/133 (69.92%) COX7B;ATP6V1G1;ATP6V0C;...
Alanine, aspartate and glutamate metabolism 1.82 8.25e-3 27/37 (72.97%) ASNS;ALDH5A1;GLUD2;...
Arginine and proline metabolism 1.79 1.34e-2 39/50 (78%) MAOA;ARG2;CKB;...
Proximal tubule bicarbonate reclamation 1.77 1.70e-2 21/23 (91.3%) CA2;GLUD2;PCK1;...
Retinol metabolism 1.75 1.93e-2 41/68 (60.29%) CYP26A1;RDH11;ALDH1A3;...
Bladder cancer 1.75 1.89e-2 40/41 (97.56%) THBS1;MMP9;CDH1;...
Mineral absorption 1.74 1.94e-2 48/60 (80%) MT1M;MT1E;SLC30A1;...
PPAR signaling pathway 1.74 1.84e-2 66/74 (89.19%) FABP5;APOA1;PCK1;...
Vitamin digestion and absorption 1.74 1.74e-2 17/24 (70.83%) APOA1;APOB;SCARB1;...
Fatty acid degradation 1.73 1.98e-2 40/43 (93.02%) ACSL1;ACSL3;ACAT2;...
Viral myocarditis 1.72 2.07e-2 53/60 (88.33%) CXADR;CAV1;RAC1;...
Vibrio cholerae infection 1.70 2.74e-2 44/50 (88%) ACTB;ATP6V1G1;ATP6V0C;...
Type I diabetes mellitus 1.68 3.24e-2 38/43 (88.37%) CPE;CD86;HLA-B;...
Synaptic vesicle cycle 1.66 3.86e-2 63/78 (80.77%) CLTC;AP2B1;SYT1;...
Fatty acid biosynthesis 1.63 4.95e-2 16/18 (88.89%) FASN;ACSL1;ACSL3;...
Galactose metabolism -1.70 4.87e-2 26/31 (83.87%) GLB1;UGP2;GALK1;...
Homologous recombination -1.79 2.13e-2 35/41 (85.37%) TOPBP1;RAD52;RAD51D;...
DNA replication -1.87 6.08e-3 34/36 (94.44%) RFC4;MCM4;MCM6;...
Fanconi anemia pathway -1.95 3.04e-3 36/54 (66.67%) HES1;FAAP24;BRCA2;...
Base excision repair -2.09 0.00e+0 29/33 (87.88%) POLL;NEIL1;LIG3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H