Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DML0YEK)

Drug Name
CATECHOL Drug Info
Synonyms
pyrocatechol; 1,2-dihydroxybenzene; 120-80-9; 1,2-benzenediol; benzene-1,2-diol; pyrocatechin; 2-hydroxyphenol; o-Benzenediol; Pyrocatechine; o-Dihydroxybenzene; Oxyphenic acid; o-Hydroxyphenol; o-Hydroquinone; o-Dioxybenzene; o-Phenylenediol; Phthalhydroquinone; Fouramine PCH; Durafur developer C; Pelagol Grey C; benzenediol; Catechin (phenol); Fourrine 68; Benzene, o-dihydroxy-; Catechol (phenol); o-Diphenol; ortho-Hydroxyphenol; Pyrokatechol; Pyrokatechin; Katechol; ortho-Dihydroxybenzene; C.I. Oxidation Base 26
Cross-matching ID
PubChem CID
289
ChEBI ID
CHEMBL280998
CAS Number
CAS 120-80-9
TTD Drug ID
D07QJJ
INTEDE Drug ID
DR2201

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Sulfur metabolism 1.93 2.77e-2 9/10 (90%) SELENBP1;PAPSS1;PAPSS2;...
Pathogenic Escherichia coli infection 1.85 3.12e-2 152/197 (77.16%) EZR;CLDN3;PAK1;...
Fructose and mannose metabolism -1.73 3.57e-2 30/33 (90.91%) HKDC1;SORD;MPI;...
Th1 and Th2 cell differentiation -1.77 2.12e-2 80/92 (86.96%) HLA-DMB;HLA-DQB1;MAPK9;...
Linoleic acid metabolism -1.80 1.59e-2 21/29 (72.41%) PLA2G4A;CYP2C8;PLA2G2D;...
Galactose metabolism -1.81 1.82e-2 26/31 (83.87%) HKDC1;GALK1;GLA;...
Cholesterol metabolism -1.81 2.12e-2 44/50 (88%) VDAC3;APOC2;LPA;...
Metabolism of xenobiotics by cytochrome P450 -1.86 1.02e-2 49/77 (63.64%) GSTK1;GSTT1;ADH1A;...
Protein digestion and absorption -1.87 1.27e-2 78/103 (75.73%) CPA1;ATP1A3;COL1A2;...
Drug metabolism -1.89 1.27e-2 78/151 (51.66%) UMPS;CYP2C8;XDH;...
Starch and sucrose metabolism -1.93 6.37e-3 25/36 (69.44%) G6PC2;PYGB;GBE1;...
Glutathione metabolism -1.93 1.27e-2 43/57 (75.44%) GSTK1;GSTT1;CHAC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 10uM - 100uM 48H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 100uM 48H