Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DML1538)

• Drug Name: Diazoxide Drug Info
• Synonyms: Aroglycem; Diazossido; Diazoxido; Diazoxidum; Dizoxide; Eudemine; Hyperstat; Hypertonalum; Mutabase; Proglicem; Proglycem; Diazossido [DCIT]; Diazossido [Italian]; D 9035; SRG 95213; Sch 6783; Diazoxido [INN-Spanish]; Diazoxidum [INN-Latin]; Hyperstat (TN); SRG-95213; Sch-6783; Diazoxide [USAN:INN:BAN]; Diazoxide (JAN/USP/INN); 2H-1,2, 4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide; 7-Chloro-3-methyl-1lambda~4~,2,4-benzothiadiazin-1-ol 1-oxide; 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido; 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]; 7-chloro-3-methyl-4H-1
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 3019
  ChEBI ID: CHEMBL181
  CAS Number: CAS 364-98-7
  TTD Drug ID: D07WEP
  ACDINA Drug ID: D01001

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
ECM-receptor interaction	2.15	0.00e+0	80/88 (90.91%)	COL4A2;AGRN;COL4A1;...
Focal adhesion	1.96	3.61e-3	180/201 (89.55%)	COL4A2;MYLK;COL4A1;...
Lysosome	-1.61	4.92e-2	115/128 (89.84%)	CTSO;CTSV;HYAL1;...
Glutathione metabolism	-1.62	4.56e-2	43/57 (75.44%)	GPX4;GGT1;PGD;...
Tyrosine metabolism	-1.62	4.45e-2	30/36 (83.33%)	DCT;MIF;HPD;...
Pancreatic secretion	-1.64	3.91e-2	87/102 (85.29%)	PLA2G1B;CELA3A;PNLIP;...
Tryptophan metabolism	-1.64	3.97e-2	35/42 (83.33%)	EHHADH;ALDH8A1;AOX1;...
Parkinson disease	-1.64	4.08e-2	176/249 (70.68%)	VDAC2;EIF2AK3;RYR3;...
Synthesis and degradation of ketone bodies	-1.65	3.67e-2	9/10 (90%)	HMGCS1;HMGCL;HMGCS2;...
Allograft rejection	-1.66	3.33e-2	32/38 (84.21%)	HLA-DMB;CD28;IL12B;...
Intestinal immune network for IgA production	-1.67	3.37e-2	38/48 (79.17%)	HLA-DMB;CCR9;CD28;...
Folate biosynthesis	-1.72	2.36e-2	23/26 (88.46%)	FPGS;PAH;ALPL;...
NF-kappa B signaling pathway	-1.75	1.63e-2	90/104 (86.54%)	BLNK;RELA;ZAP70;...
Other glycan degradation	-1.75	1.65e-2	13/18 (72.22%)	MAN2B2;MANBA;GLB1;...
Nitrogen metabolism	-1.76	1.60e-2	16/17 (94.12%)	CA14;CA4;CPS1;...
IL-17 signaling pathway	-1.77	1.32e-2	84/94 (89.36%)	JUN;FOSL1;FOSB;...
Oxidative phosphorylation	-1.79	1.16e-2	93/133 (69.92%)	ATP5F1C;ATP6V1F;NDUFA6;...
Drug metabolism	-1.80	1.06e-2	78/151 (51.66%)	CYP2C9;AOX1;NAT1;...
Pentose phosphate pathway	-1.81	9.54e-3	25/30 (83.33%)	TKT;G6PD;PGLS;...
Ubiquinone and other terpenoid-quinone biosynthesis	-1.82	9.30e-3	9/11 (81.82%)	COQ3;COQ7;GGCX;...
Graft-versus-host disease	-1.82	7.89e-3	32/42 (76.19%)	KIR3DL1;KIR2DL3;HLA-DMB;...
Ribosome	-1.83	7.44e-3	113/158 (71.52%)	MRPL11;RPS3A;MRPL23;...
Steroid biosynthesis	-1.87	2.76e-3	19/20 (95%)	NSDHL;SC5D;CYP27B1;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.92	0.00e+0	62/70 (88.57%)	PLCG1;IKBKB;CXCR1;...
Mineral absorption	-2.00	0.00e+0	48/60 (80%)	ATP7A;FTL;ATOX1;...
Proximal tubule bicarbonate reclamation	-2.03	0.00e+0	21/23 (91.3%)	CA4;ATP1B3;AQP1;...
Type I diabetes mellitus	-2.06	0.00e+0	38/43 (88.37%)	HLA-DMB;CD28;INS;...
Autoimmune thyroid disease	-2.10	0.00e+0	46/53 (86.79%)	PRF1;CD40LG;HLA-DRB1;...
Retinol metabolism	-2.14	0.00e+0	41/68 (60.29%)	CYP26A1;CYP2C9;AOX1;...
Pentose and glucuronate interconversions	-2.18	0.00e+0	17/34 (50%)	UGT2B28;AKR1A1;UGT2B17;...
Metabolism of xenobiotics by cytochrome P450	-2.30	0.00e+0	49/77 (63.64%)	CYP2C9;ADH1B;GSTA4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	20uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	15uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼