General Information of Drug (ID: DML2NIB)

Drug Name
Aminophylline Drug Info
Synonyms
Aminocardol; Aminodur; Aminofilina; Aminofillina; Aminophyllin; Ammophyllin; Cardiofilina; Cardiomin; Cardophylin; Cardophyllin; Carena; Cariomin; DOBO; Diaphilline; Diaphyllin; Diaphylline; Diophllin; Diophyllin; Diuxanthine; Ethophylline; Eufilina; Euphyllin; Euphylline; Euphyllinum; Eurphyllin; Euufilin; Euufillin; Genophyllin; Grifomin; Inophylline; Lasodex; Linampheta; Lixaminol; Metaphyllin; Metaphylline; Minaphil; Miofilin; Neophyiline; Norofilina; Peterphyllin; Phylcardin; Phyllindon; Phyllocontin; Phyllotemp; Somophyllin; Stenovasan; Syntophyllin; Theodrox; Theolamine; Theolone; Theomin; Theophyldine; Thephyldine; Truphylline; Vasofilina; A 1755; BY 108; Minomal(TN); Phyllocontin (TN); TH/100; Truphylline (TN)
Therapeutic ClassBronchodilator Agents
Cross-matching ID
PubChem CID
9433
ChEBI ID
CHEMBL1370561
CAS Number
CAS 317-34-0
TTD Drug ID
D03TYI
INTEDE Drug ID
DR0090

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Systemic lupus erythematosus 1.67 4.66e-1 45/135 (33.33%) C7;FCGR3B;C3;...
Tuberculosis 1.62 4.32e-1 159/180 (88.33%) CASP10;CTSS;FCGR3B;...
Fc gamma R-mediated phagocytosis 1.58 4.40e-1 79/97 (81.44%) CDC42;PAK1;FCGR3B;...
Pentose and glucuronate interconversions 1.57 3.70e-1 17/34 (50%) UGT2B28;UGP2;GUSB;...
Sphingolipid metabolism 1.55 3.91e-1 32/49 (65.31%) DEGS1;GALC;PLPP2;...
Regulation of lipolysis in adipocytes 1.55 3.40e-1 52/55 (94.55%) PLIN1;INSR;PLAAT3;...
Retinol metabolism 1.51 4.11e-1 41/68 (60.29%) UGT2B28;DHRS3;ADH1B;...
Carbohydrate digestion and absorption 1.48 4.82e-1 37/47 (78.72%) PLCB1;ATP1A2;PRKCB;...
Amoebiasis 1.48 4.39e-1 99/102 (97.06%) COL4A5;ARG1;COL4A6;...
Leishmaniasis 1.48 4.04e-1 67/77 (87.01%) FCGR3B;CYBA;C3;...
Tyrosine metabolism 1.47 4.04e-1 30/36 (83.33%) AOC3;ADH1B;AOX1;...
Non-alcoholic fatty liver disease 1.46 3.89e-1 126/155 (81.29%) CDC42;ADIPOQ;INSR;...
Apoptosis 1.44 4.18e-1 126/168 (75%) CASP10;TNFSF10;CTSS;...
Intestinal immune network for IgA production 1.44 3.92e-1 38/48 (79.17%) HLA-DPB1;HLA-DQB1;IL6;...
RIG-I-like receptor signaling pathway 1.44 3.79e-1 64/70 (91.43%) CASP10;DDX58;CASP8;...
Antigen processing and presentation 1.42 4.02e-1 60/78 (76.92%) CTSS;LGMN;HSPA1A;...
Ascorbate and aldarate metabolism 1.42 3.97e-1 15/30 (50%) UGT2B28;GUSB;ALDH9A1;...
Natural killer cell mediated cytotoxicity 1.40 4.18e-1 99/131 (75.57%) TNFSF10;PAK1;FCGR3B;...
Insulin signaling pathway 1.40 4.18e-1 121/137 (88.32%) INSR;CRK;BAD;...
Epithelial cell signaling in Helicobacter pylori infect... 1.39 4.20e-1 62/70 (88.57%) CDC42;PAK1;CXCL1;...
Focal adhesion 1.36 4.87e-1 180/201 (89.55%) COL4A5;CDC42;PAK1;...
Hepatitis B 1.36 4.83e-1 151/162 (93.21%) CASP10;EGR3;BAD;...
Protein processing in endoplasmic reticulum 1.36 4.70e-1 127/171 (74.27%) SEL1L;DERL2;HSPA1A;...
Tight junction 1.35 4.61e-1 130/169 (76.92%) CDC42;CLDN8;HCLS1;...
Bacterial invasion of epithelial cells 1.35 4.51e-1 59/77 (76.62%) CDC42;HCLS1;CRK;...
Viral myocarditis 1.35 4.40e-1 53/60 (88.33%) BID;DMD;HLA-DPB1;...
Herpes simplex virus 1 infection 1.34 4.53e-1 165/498 (33.13%) BST2;BAD;BID;...
Leukocyte transendothelial migration 1.33 4.74e-1 90/114 (78.95%) CDC42;CLDN8;CYBA;...
Pertussis 1.32 5.06e-1 64/76 (84.21%) SERPING1;CALML5;GNAI1;...
Gastric acid secretion 1.31 5.06e-1 63/76 (82.89%) PLCB1;CALML5;GNAI1;...
Bladder cancer -1.23 4.79e-1 40/41 (97.56%) E2F2;THBS1;FGFR3;...
Fat digestion and absorption -1.23 4.88e-1 35/43 (81.4%) PNLIPRP2;APOA4;CLPS;...
Th1 and Th2 cell differentiation -1.24 4.89e-1 80/92 (86.96%) JUN;NFATC1;CD3G;...
Steroid biosynthesis -1.25 4.79e-1 19/20 (95%) NSDHL;EBP;CYP24A1;...
RNA polymerase -1.26 4.74e-1 23/31 (74.19%) POLR3F;POLR3K;POLR3C;...
Salivary secretion -1.26 4.70e-1 76/93 (81.72%) CST2;PRKCA;ATP1A1;...
Maturity onset diabetes of the young -1.27 4.74e-1 21/26 (80.77%) HHEX;HNF4G;HNF1B;...
Fructose and mannose metabolism -1.28 4.59e-1 30/33 (90.91%) FBP1;PMM1;HKDC1;...
NF-kappa B signaling pathway -1.31 3.94e-1 90/104 (86.54%) ZAP70;MALT1;PLCG1;...
Alanine, aspartate and glutamate metabolism -1.32 3.77e-1 27/37 (72.97%) CAD;ASL;GLS2;...
Glyoxylate and dicarboxylate metabolism -1.32 3.88e-1 23/30 (76.67%) PGP;AMT;GRHPR;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.33 3.80e-1 79/89 (88.76%) JUN;NFATC1;PIK3CA;...
Glucagon signaling pathway -1.33 3.96e-1 89/107 (83.18%) PPARA;PRKAG1;CPT1A;...
Purine metabolism -1.34 3.91e-1 102/129 (79.07%) ADSL;PDE1A;NME3;...
Butanoate metabolism -1.34 4.00e-1 23/28 (82.14%) ABAT;GAD1;HMGCS2;...
Protein digestion and absorption -1.35 4.09e-1 78/103 (75.73%) XPNPEP2;CPA1;CELA3A;...
Malaria -1.35 4.34e-1 44/50 (88%) KLRB1;CR1;GYPA;...
Sulfur metabolism -1.35 4.50e-1 9/10 (90%) ETHE1;TST;MPST;...
TGF-beta signaling pathway -1.36 4.53e-1 81/94 (86.17%) LTBP1;TGIF2;SMURF1;...
Nicotinate and nicotinamide metabolism -1.38 4.45e-1 25/35 (71.43%) NNT;NMNAT2;NMRK1;...
Other types of O-glycan biosynthesis -1.41 3.78e-1 29/47 (61.7%) POGLUT1;COLGALT2;POFUT1;...
Pancreatic secretion -1.41 4.01e-1 87/102 (85.29%) SLC12A2;PLA2G2A;PLA2G2F;...
Other glycan degradation -1.43 3.86e-1 13/18 (72.22%) MAN2B2;MAN2C1;ENGASE;...
Primary immunodeficiency -1.44 3.94e-1 33/38 (86.84%) IGLL1;CD40LG;DCLRE1C;...
Ribosome -1.44 4.39e-1 113/158 (71.52%) RPL4;MRPL17;MRPL35;...
RNA degradation -1.48 3.61e-1 53/79 (67.09%) MTREX;PABPC1;EXOSC9;...
Central carbon metabolism in cancer -1.51 3.19e-1 67/70 (95.71%) PGAM1;MET;PFKM;...
Sulfur relay system -1.52 3.49e-1 5/8 (62.5%) TST;MPST;MOCS2;...
Synthesis and degradation of ketone bodies -1.52 4.35e-1 9/10 (90%) HMGCS2;ACAT2
Mucin type O-glycan biosynthesis -1.59 4.90e-1 20/36 (55.56%) GCNT3;ST6GALNAC4;GALNT7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H