Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DML51D0)

Drug Name
UCL-2000; butabindide Drug Info
Cross-matching ID
TTD Drug ID
D0T7CM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.07 0.00e+0 80/88 (90.91%) TNC;SDC1;ITGA5;...
Viral protein interaction with cytokine and cytokine re... 1.85 4.71e-2 84/100 (84%) CX3CR1;CXCL9;CXCL1;...
Legionellosis 1.84 4.04e-2 51/57 (89.47%) TLR4;EEF1A2;CXCL1;...
Hypertrophic cardiomyopathy 1.82 3.43e-2 81/90 (90%) DES;CACNA2D2;ITGA5;...
Primary immunodeficiency 1.82 2.86e-2 33/38 (86.84%) IL7R;IGLL1;CD3D;...
Hematopoietic cell lineage 1.80 2.89e-2 90/99 (90.91%) IL7R;ITGA5;CD14;...
Rheumatoid arthritis 1.80 2.53e-2 78/93 (83.87%) TLR4;ANGPT1;CXCL1;...
Leishmaniasis 1.79 2.36e-2 67/77 (87.01%) TLR4;EEF1A2;TLR2;...
Cytokine-cytokine receptor interaction 1.77 2.63e-2 246/295 (83.39%) CX3CR1;IL7R;IL13RA2;...
Pertussis 1.76 3.03e-2 64/76 (84.21%) TLR4;C1QA;ITGA5;...
Tryptophan metabolism 1.75 2.78e-2 35/42 (83.33%) AOX1;TDO2;DLD;...
Malaria 1.73 3.65e-2 44/50 (88%) TLR4;SDC1;TLR2;...
Dilated cardiomyopathy 1.69 4.33e-2 86/96 (89.58%) DES;PLN;CACNA2D2;...
Arginine biosynthesis -1.91 6.60e-3 17/22 (77.27%) OTC;GLUD2;ARG1;...
Mineral absorption -1.93 0.00e+0 48/60 (80%) ATP1B2;SLC31A1;MT1X;...
Protein export -1.96 0.00e+0 17/23 (73.91%) SRP54;SEC63;SEC61B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H