Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DML5DU0)

Drug Name
YM90709 Drug Info
Synonyms YM-90709; YM 90709
Cross-matching ID
PubChem CID
1103147
ChEBI ID
CHEMBL92125
CAS Number
CAS 163769-88-8
TTD Drug ID
D0S2TI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral protein interaction with cytokine and cytokine re... 2.03 1.99e-2 84/100 (84%) CXCL5;CXCL3;CXCL1;...
TNF signaling pathway 2.01 9.97e-3 103/112 (91.96%) CXCL5;CXCL3;CXCL1;...
Drug metabolism -1.76 2.76e-2 78/151 (51.66%) MAOA;UGT2B15;UGT2A3;...
Retinol metabolism -1.77 3.01e-2 41/68 (60.29%) PNPLA4;LRAT;CYP2C18;...
Cholesterol metabolism -1.91 3.34e-3 44/50 (88%) ABCB11;APOE;APOA4;...
Mineral absorption -1.93 4.01e-3 48/60 (80%) FTH1;MT1M;ATP7B;...
Metabolism of xenobiotics by cytochrome P450 -2.12 0.00e+0 49/77 (63.64%) UGT2B15;CYP1A1;UGT2A3;...
Complement and coagulation cascades -2.18 0.00e+0 76/85 (89.41%) SERPINF2;THBD;CFHR2;...
Steroid hormone biosynthesis -2.23 0.00e+0 43/61 (70.49%) CYP3A7;CYP17A1;HSD17B1;...
Steroid biosynthesis -2.39 0.00e+0 19/20 (95%) LIPA;TM7SF2;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H