Details of the Drug Pharmacogenomic Perturbation Atlas

RN486 Drug Info

RN-486; compound 29 [PMID 22394077]

Cross-matching ID

PubChem CID

46908026

ChEBI ID

CHEMBL2057918

CAS Number

CAS 1242156-23-5

TTD Drug ID

D0N0LN

General Information of Drug (ID: DML7SQH)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	-1.64	4.75e-2	44/50 (88%)	IL10;MET;TGFB1;...
AGE-RAGE signaling pathway in diabetic complications	-1.64	4.99e-2	97/100 (97%)	VEGFD;PRKCZ;EDN1;...
C-type lectin receptor signaling pathway	-1.66	4.98e-2	93/104 (89.42%)	RRAS;NLRP3;MAPK9;...
B cell receptor signaling pathway	-1.70	4.10e-2	71/81 (87.65%)	CD79A;JUN;SYK;...
Fatty acid degradation	-1.70	4.28e-2	40/43 (93.02%)	HADHA;ACADVL;ECI2;...
Rheumatoid arthritis	-1.71	4.75e-2	78/93 (83.87%)	CSF2;TGFB1;TNFSF11;...
Amoebiasis	-1.73	4.16e-2	99/102 (97.06%)	GNAL;IL10;RAB5A;...
Osteoclast differentiation	-1.74	4.24e-2	117/127 (92.13%)	TGFB1;MAPK9;TNFSF11;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.75	4.55e-2	62/70 (88.57%)	MAPK9;CSK;PTPRZ1;...
Pathogenic Escherichia coli infection	-1.76	4.52e-2	152/197 (77.16%)	PYCARD;CDC42;CTTN;...
TNF signaling pathway	-1.83	3.96e-2	103/112 (91.96%)	CSF2;BIRC3;MAPK9;...
Retinol metabolism	-1.88	2.38e-2	41/68 (60.29%)	HSD17B6;RDH16;CYP2B6;...
NF-kappa B signaling pathway	-2.02	1.19e-2	90/104 (86.54%)	BIRC3;CSNK2A1;TNFSF11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
K-562	CVCL_0004	Homo sapiens	0.01uM - 10uM	24H

Multiple myeloma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
KMS-34	CVCL_1333	Homo sapiens	0.01uM - 10uM	24H

Lymph node

Burkitt lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BJAB	CVCL_5711	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Diffuse large B-cell lymphoma

Mantle cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MINO	CVCL_4965	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Peripheral blood

Acute B-lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NALM-6	CVCL_0092	Homo sapiens	0.01uM - 10uM	24H

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-MEL-5	CVCL_0527	Homo sapiens	0.01uM - 10uM	24H