Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DML9UFD)

Drug Name
Kirromycin Drug Info
Cross-matching ID
PubChem CID
135484176
CAS Number
CAS 50935-71-2
TTD Drug ID
D0OG4A

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Arachidonic acid metabolism 2.00 1.98e-2 48/61 (78.69%) CYP2E1;GPX1;PLA2G4C;...
Linoleic acid metabolism 1.87 2.96e-2 21/29 (72.41%) CYP2E1;PLA2G4C;PLA2G2A;...
Salivary secretion 1.86 1.98e-2 76/93 (81.72%) CST1;FXYD2;GUCY1A1;...
Metabolism of xenobiotics by cytochrome P450 1.84 1.73e-2 49/77 (63.64%) ALDH3A1;CYP2E1;GSTO1;...
Retinol metabolism 1.74 4.35e-2 41/68 (60.29%) ALDH1A1;RDH11;UGT2B28;...
Drug metabolism 1.73 3.79e-2 78/151 (51.66%) ALDH3A1;CYP2E1;GSTO1;...
Glycine, serine and threonine metabolism -1.98 1.01e-2 31/40 (77.5%) SRR;PSPH;SHMT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H