Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLDBQ5)

Drug Name
SEN-196 Drug Info
Synonyms EX-527; SEN-0014196; SIRT1 inhibitors (Huntingtons disease), Elixir/Siena; Sirtuin-1 inhibitors (oral, Huntington's disease), Elixir/Siena
Cross-matching ID
PubChem CID
5113032
ChEBI ID
CHEMBL90369
CAS Number
CAS 49843-98-3
TTD Drug ID
D0E3LP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.46 0.00e+0 34/36 (94.44%) RFC3;MCM6;RNASEH2A;...
Cell cycle 2.34 0.00e+0 110/124 (88.71%) CCNB2;CCNA2;CCNE2;...
Spliceosome 2.14 0.00e+0 101/150 (67.33%) PRPF4;SRSF7;RBMX;...
RNA transport 2.13 0.00e+0 128/186 (68.82%) EIF1AX;RAN;NUP37;...
Fanconi anemia pathway 2.01 0.00e+0 36/54 (66.67%) BRCA1;FANCI;USP1;...
Homologous recombination 1.97 1.66e-3 35/41 (85.37%) BRCA1;RAD54B;RAD51;...
RNA degradation 1.93 1.42e-3 53/79 (67.09%) CNOT7;LSM2;HSPD1;...
RNA polymerase 1.89 1.24e-3 23/31 (74.19%) POLR2D;POLR3K;POLR3B;...
Citrate cycle (TCA cycle) 1.89 1.10e-3 30/30 (100%) DLD;IDH2;IDH3A;...
Ribosome 1.88 1.49e-3 113/158 (71.52%) MRPL15;RSL24D1;RPS5;...
Propanoate metabolism 1.86 1.81e-3 30/34 (88.24%) DLD;PCCB;ACAT2;...
Ribosome biogenesis in eukaryotes 1.85 2.48e-3 52/108 (48.15%) RAN;GNL3;RBM28;...
Base excision repair 1.84 2.29e-3 29/33 (87.88%) HMGB1;FEN1;NEIL3;...
Oxidative phosphorylation 1.82 3.55e-3 93/133 (69.92%) CYC1;NDUFA5;NDUFA7;...
Mismatch repair 1.81 3.64e-3 22/23 (95.65%) RFC3;MSH6;RFC5;...
One carbon pool by folate 1.80 3.72e-3 15/20 (75%) TYMS;MTHFD2;MTHFD1;...
Oocyte meiosis 1.72 1.17e-2 90/129 (69.77%) CCNB2;CCNE2;SMC1A;...
Progesterone-mediated oocyte maturation 1.68 1.66e-2 75/100 (75%) CCNB2;CCNA2;CDK1;...
Basal transcription factors 1.65 1.88e-2 37/45 (82.22%) MNAT1;TAF7;TAF5;...
Non-homologous end-joining 1.63 2.23e-2 11/13 (84.62%) FEN1;PRKDC;DNTT;...
mRNA surveillance pathway 1.59 2.65e-2 71/98 (72.45%) CPSF7;PPP2R5E;SRRM1;...
Nucleotide excision repair 1.57 2.98e-2 40/47 (85.11%) MNAT1;RFC3;POLE2;...
Malaria -1.69 2.61e-2 44/50 (88%) MYD88;IL10;CCL2;...
Osteoclast differentiation -1.70 2.51e-2 117/127 (92.13%) AKT3;LILRB2;PIK3CD;...
C-type lectin receptor signaling pathway -1.70 2.45e-2 93/104 (89.42%) PIK3CD;MALT1;NFATC1;...
Ovarian steroidogenesis -1.71 2.29e-2 41/51 (80.39%) HSD17B2;SCARB1;CYP17A1;...
Sphingolipid metabolism -1.72 1.95e-2 32/49 (65.31%) CERS2;GAL3ST1;SPTLC2;...
Primary bile acid biosynthesis -1.74 1.59e-2 15/17 (88.24%) BAAT;CYP7A1;CYP39A1;...
Lysosome -1.74 1.49e-2 115/128 (89.84%) ARSA;LIPA;NAGPA;...
Amoebiasis -1.78 1.01e-2 99/102 (97.06%) LAMA5;LAMC3;TGFB1;...
Protein digestion and absorption -1.80 9.97e-3 78/103 (75.73%) COL7A1;SLC15A1;ATP1A2;...
NOD-like receptor signaling pathway -1.80 9.14e-3 145/181 (80.11%) IKBKB;MEFV;FADD;...
Rheumatoid arthritis -1.81 8.91e-3 78/93 (83.87%) TGFB1;HLA-DMB;IL15;...
Pertussis -1.83 7.94e-3 64/76 (84.21%) LY96;MYD88;IL10;...
Cytokine-cytokine receptor interaction -1.84 6.86e-3 246/295 (83.39%) IL10;CCL19;CSF3R;...
Ascorbate and aldarate metabolism -1.84 6.45e-3 15/30 (50%) GUSB;ALDH2;RGN;...
Kaposi sarcoma-associated herpesvirus infection -1.84 6.00e-3 172/193 (89.12%) ATG14;PLCG2;NFKB1;...
Porphyrin and chlorophyll metabolism -1.85 6.40e-3 23/43 (53.49%) GUSB;CP;ALAS2;...
Hematopoietic cell lineage -1.86 3.92e-3 90/99 (90.91%) HLA-DMB;CSF2;IL2RA;...
ABC transporters -1.90 1.05e-3 37/45 (82.22%) ABCA12;ABCG5;DEFB1;...
Metabolism of xenobiotics by cytochrome P450 -1.92 0.00e+0 49/77 (63.64%) CYP2B6;GSTT2;CYP2D6;...
Phagosome -1.95 0.00e+0 118/152 (77.63%) HGS;FCGR2A;TLR6;...
Ferroptosis -1.98 0.00e+0 36/41 (87.8%) ACSL4;PRNP;GCLM;...
Glycerolipid metabolism -2.01 0.00e+0 44/61 (72.13%) LPL;ALDH2;PLPP3;...
Bile secretion -2.02 0.00e+0 68/90 (75.56%) ABCB11;ABCC4;HMGCR;...
Steroid hormone biosynthesis -2.07 0.00e+0 43/61 (70.49%) HSD17B2;SULT2B1;HSD17B3;...
Cholesterol metabolism -2.11 0.00e+0 44/50 (88%) LRP1;ABCG5;LPL;...
Retinol metabolism -2.20 0.00e+0 41/68 (60.29%) ADH6;CYP3A7;DHRS9;...
NF-kappa B signaling pathway -2.20 0.00e+0 90/104 (86.54%) EDAR;GADD45B;GADD45G;...
Mineral absorption -2.33 0.00e+0 48/60 (80%) SLC11A2;HMOX2;SLC26A3;...
PPAR signaling pathway -2.33 0.00e+0 66/74 (89.19%) RXRA;CYP7A1;ADIPOQ;...
Complement and coagulation cascades -2.60 0.00e+0 76/85 (89.41%) C8G;F10;PLAU;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 25uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 25uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 25uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 25uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 25uM 6H
MDST8 CVCL_1400 Homo sapiens 25uM 6H
NCI-H508 CVCL_1561 Homo sapiens 25uM 6H
SNU-1040 CVCL_5001 Homo sapiens 25uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 25uM 6H
SNU-C5 CVCL_5009 Homo sapiens 25uM 6H
SW480 CVCL_0546 Homo sapiens 25uM 6H
SW620 CVCL_0547 Homo sapiens 25uM 6H
SW948 CVCL_0550 Homo sapiens 25uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 25uM 6H
HT115 CVCL_1294 Homo sapiens 25uM 6H
RKO CVCL_0504 Homo sapiens 25uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 25uM 6H, 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 25uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 25uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 25uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 25uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 1.11uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 25uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 25uM 6H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 25uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 25uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 25uM 6H
T3M-10 CVCL_1729 Homo sapiens 25uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 25uM 6H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 25uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 25uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 25uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 25uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 25uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 25uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 25uM 6H
OV7 CVCL_1623 Homo sapiens 25uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 25uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 25uM 6H
RMUG-S CVCL_1666 Homo sapiens 25uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 25uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 6H, 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 25uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 25uM 6H
PL-21 CVCL_2161 Homo sapiens 25uM 6H
SKM-1 CVCL_0010 Homo sapiens 25uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 25uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 25uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 25uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 25uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 25uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 25uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 25uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H