Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLFZHD)

• Drug Name: Aclarubicin Drug Info
• Synonyms: Aclacin; Aclacur; Aclarubicine; Aclarubicino; Aclarubicinum; Jaclacin; Aclacinomycin A; Aclucinomycin A; Antibiotic MA 144A; Antibiotic MA 144A1; Antibiotic MA 144G1; MA 144G1; Aclarubicine [INN-French]; Aclarubicino [INN-Spanish]; Aclarubicinum [INN-Latin]; Antibiotic MA144-A1; MA 144-A1; MA-144A1; Acene-1-carboxylate; Aclarubicin (USAN/INN); Aclarubicin [USAN:BAN:INN]; Alpha-L-lyxo-hexopyranosyl]-oxy]-1-naphthacenecarboxalic acid methyl ester; 10-epi-Aclacinomycin A
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 451415
  ChEBI ID: CHEMBL502620
  CAS Number: CAS 57576-44-0
  TTD Drug ID: D01UBX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Rheumatoid arthritis	2.14	0.00e+0	78/93 (83.87%)	CXCL8;CCL20;FOS;...
IL-17 signaling pathway	1.91	1.90e-2	84/94 (89.36%)	CXCL8;CCL20;FOS;...
Malaria	1.91	1.27e-2	44/50 (88%)	VCAM1;CXCL8;TGFB1;...
Th17 cell differentiation	1.85	1.27e-2	95/107 (88.79%)	FOS;TGFB1;TGFBR2;...
Hematopoietic cell lineage	1.82	1.78e-2	90/99 (90.91%)	ITGB3;CSF1R;CD36;...
Inflammatory bowel disease	1.80	2.33e-2	58/65 (89.23%)	TGFB1;HLA-DQB1;GATA3;...
Asthma	1.79	2.36e-2	25/31 (80.65%)	HLA-DQB1;FCER1A;HLA-DPA1;...
Notch signaling pathway	-1.95	1.44e-2	49/59 (83.05%)	CREBBP;HDAC1;RBPJ;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	4uM	72H	Hide ▲