Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLG05U)

Drug Name
NSC-625987 Drug Info
Synonyms NSC 625987
Cross-matching ID
PubChem CID
3004085
ChEBI ID
CHEMBL1331734
CAS Number
CAS 141992-47-4
TTD Drug ID
D0VD8B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Vibrio cholerae infection 2.04 0.00e+0 44/50 (88%) TJP1;ATP6V1C1;ATP6V1B2;...
Protein export 1.91 2.36e-2 17/23 (73.91%) SEC62;SRP14;SRP54;...
SNARE interactions in vesicular transport 1.91 1.57e-2 19/33 (57.58%) BET1;STX3;STX1A;...
Progesterone-mediated oocyte maturation 1.82 3.54e-2 75/100 (75%) CCNA1;CCNA2;IGF1;...
Selenocompound metabolism 1.80 3.78e-2 11/17 (64.71%) PAPSS2;CTH;TXNRD1
Glycine, serine and threonine metabolism 1.77 3.93e-2 31/40 (77.5%) PSAT1;CTH;MAOA;...
Autophagy 1.73 4.85e-2 113/169 (66.86%) DDIT4;ATG3;NRBF2;...
Oxidative phosphorylation 1.72 4.37e-2 93/133 (69.92%) NDUFA4;ATP6V1C1;ATP6V1B2;...
Steroid biosynthesis 1.71 4.09e-2 19/20 (95%) DHCR24;SQLE;DHCR7;...
Starch and sucrose metabolism -1.77 4.92e-2 25/36 (69.44%) GPI;GYS1;HK1;...
Galactose metabolism -1.92 5.27e-3 26/31 (83.87%) HK1;PFKM;MGAM;...
ECM-receptor interaction -1.94 1.05e-2 80/88 (90.91%) THBS3;LAMC1;COL6A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H