Details of the Drug Pharmacogenomic Perturbation Atlas

Ridaforolimus Drug Info

Deforolimus; AP 23573; MK 8669; AP-23573; MK-8669; AP23573, MK-8669, Ridaforolimus, Deforolimus

Cross-matching ID

PubChem CID

11520894

ChEBI ID

CHEMBL79700

CAS Number

CAS 572924-54-0

TTD Drug ID

D0O3CV

General Information of Drug (ID: DMLHEU7)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Lysosome	2.04	0.00e+0	115/128 (89.84%)	PSAP;NPC2;GALC;...
ECM-receptor interaction	1.97	0.00e+0	80/88 (90.91%)	ITGB5;THBS1;SDC4;...
Transcriptional misregulation in cancer	1.78	4.56e-2	158/192 (82.29%)	DUSP6;MYC;TP53;...
Fructose and mannose metabolism	-1.65	4.24e-2	30/33 (90.91%)	PFKFB2;ALDOA;PFKP;...
Aminoacyl-tRNA biosynthesis	-1.75	1.38e-2	15/66 (22.73%)	IARS2;FARSA;QRSL1;...
Arginine biosynthesis	-1.77	8.74e-3	17/22 (77.27%)	GOT2;GOT1;ASS1;...
RNA transport	-1.79	7.24e-3	128/186 (68.82%)	EIF2B4;NXF1;EIF1AY;...
Alanine, aspartate and glutamate metabolism	-1.80	7.06e-3	27/37 (72.97%)	NIT2;ALDH4A1;GFPT1;...
DNA replication	-1.86	3.42e-3	34/36 (94.44%)	SSBP1;MCM4;MCM2;...
PPAR signaling pathway	-1.88	3.77e-3	66/74 (89.19%)	PCK1;ACSBG1;PLIN2;...
Folate biosynthesis	-1.92	3.14e-3	23/26 (88.46%)	ALPI;SPR;TPH1;...
Glycine, serine and threonine metabolism	-1.95	3.53e-3	31/40 (77.5%)	GCAT;PGAM1;PIPOX;...
Cysteine and methionine metabolism	-1.97	1.35e-3	43/50 (86%)	GOT2;DNMT3B;AMD1;...
Terpenoid backbone biosynthesis	-1.98	1.57e-3	18/22 (81.82%)	PCYOX1;MVK;DHDDS;...
Citrate cycle (TCA cycle)	-1.98	1.88e-3	30/30 (100%)	PDHA1;FH;SUCLG1;...
Steroid biosynthesis	-2.03	0.00e+0	19/20 (95%)	SOAT2;SC5D;FDFT1;...
Biosynthesis of unsaturated fatty acids	-2.03	0.00e+0	21/27 (77.78%)	ELOVL2;ACOT7;HACD1;...
Ribosome biogenesis in eukaryotes	-2.22	0.00e+0	52/108 (48.15%)	GNL2;NXF1;EIF6;...
Proteasome	-2.50	0.00e+0	44/46 (95.65%)	PSMD3;PSMC3;PSMB8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Normal (Fibroblast)

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H