Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLK4WO)

Drug Name
8R-Lisuride Drug Info
Synonyms
BKRGVLQUQGGVSM-RDTXWAMCSA-N; S-(-)-Lisuride; 8R-lisuride; NCGC00163158-01; Biomol-NT_000024; Lopac0_000781; BPBio1_001092; CHEMBL1528238; CHEBI:93550; BDBM22867; CCG-204866; L-122; EU-0100781; SR-01000075971; SR-01000075971-1; BRD-K88871508-001-01-9; 1,1-diethyl-3-(9,10-didehydro-6-methyl-8beta-ergolinyl)urea; N'-(9,10-Didehydro-6-methylergoline-8beta-yl)-N,N-diethylurea; 1,1-diethyl-3-[(8beta)-6-methyl-9,10-didehydroergolin-8-yl]urea; S(-)-N'-[(8a)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethyl-urea
Cross-matching ID
PubChem CID
11957615
ChEBI ID
CHEMBL93550
CAS Number
CAS 140387-89-9
TTD Drug ID
D0Y5QR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis -1.70 4.52e-2 36/41 (87.8%) ACSL3;ATG5;GCLM;...
IL-17 signaling pathway -1.70 4.84e-2 84/94 (89.36%) LCN2;DEFB4A;TRAF3;...
Mitophagy -1.76 3.47e-2 56/68 (82.35%) TBC1D17;ULK1;CSNK2A2;...
TNF signaling pathway -1.76 3.39e-2 103/112 (91.96%) AKT3;PIK3R1;PIK3CA;...
Retinol metabolism -1.77 3.14e-2 41/68 (60.29%) RDH16;CYP26B1;ADH1A;...
Terpenoid backbone biosynthesis -1.77 3.53e-2 18/22 (81.82%) ACAT1;PMVK;HMGCS1;...
RIG-I-like receptor signaling pathway -1.79 4.04e-2 64/70 (91.43%) IKBKB;TKFC;FADD;...
Bile secretion -1.80 3.77e-2 68/90 (75.56%) ABCG5;ADCY9;UGT2A3;...
Fluid shear stress and atherosclerosis -1.81 3.39e-2 123/139 (88.49%) AKT3;PIK3R1;SQSTM1;...
Steroid biosynthesis -1.87 2.47e-2 19/20 (95%) FDFT1;CYP27B1;DHCR24;...
Drug metabolism -1.87 3.30e-2 78/151 (51.66%) UGT2A3;ADH6;GSTM1;...
Metabolism of xenobiotics by cytochrome P450 -1.90 2.83e-2 49/77 (63.64%) UGT2A3;ADH6;GSTM1;...
Steroid hormone biosynthesis -2.28 0.00e+0 43/61 (70.49%) AKR1D1;HSD3B1;COMT;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H