Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLMXE0)

• Drug Name: Amprenavir Drug Info
• Synonyms: AMV; Agenerase; Amprenavir[usan]; Prozei; Vertex; Amprenavir [USAN]; VX 478; VX478; Vertex VX478; Agenerase (TM); Agenerase (TN); DRG-0258; GNA & Amprenavir; HHA & Amprenavir; KVX-478; VX-478; Amprenavir (JAN/USAN/INN); Tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER; [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Galanthus nivalis agglutinin (GNA); Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3S)-tetrahydro-3-furanyl ester & Hippeastrum hybrid agglutinin(HHA); (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate; (3S)-Tetrahydro-3-furyl ((alphaS)-alpha-((1R-1-hydroxy-2-(N(sup 1)-isobutylsulfanilamido)ethyl)phenethyl)carbamate; (3S)-tetrahydro-3-furyl N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxy-propyl]carbamate; (3S-(3R*(1R*,2S*)))-(3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl) tetrahydro-3-furanyl carbamate; 4-Amino-N-((2 syn,3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutyl-benzenesulfonamide
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 65016
  ChEBI ID: CHEMBL116
  CAS Number: CAS 161814-49-9
  TTD Drug ID: D0A0OO
  VARIDT Drug ID: DR00584
  INTEDE Drug ID: DR0107

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
PPAR signaling pathway	1.95	3.05e-2	66/74 (89.19%)	FABP7;HMGCS1;ACSL1;...
Asthma	1.87	3.81e-2	25/31 (80.65%)	HLA-DQA1;HLA-DQB1;HLA-DPA1;...
Proximal tubule bicarbonate reclamation	1.86	2.54e-2	21/23 (91.3%)	CA2;SLC4A4;ATP1A2;...
Autoimmune thyroid disease	1.78	4.58e-2	46/53 (86.79%)	HLA-DQA1;HLA-DQB1;HLA-DPA1;...
alpha-Linolenic acid metabolism	1.78	3.81e-2	17/25 (68%)	ACAA1;PLA2G4C;PLAAT3;...
Type I diabetes mellitus	1.67	4.99e-2	38/43 (88.37%)	PTPRN2;HLA-DQA1;HLA-DQB1;...
Shigellosis	-1.83	2.52e-2	180/246 (73.17%)	C3;PLCG1;ARPC1A;...
Pentose phosphate pathway	-1.88	1.26e-2	25/30 (83.33%)	PFKL;PRPS1;ALDOA;...
Porphyrin and chlorophyll metabolism	-1.92	1.26e-2	23/43 (53.49%)	CPOX;UGT2B28;HEPH;...
Glutathione metabolism	-1.93	1.89e-2	43/57 (75.44%)	GSTK1;GPX3;GSTM4;...
Glycolysis / Gluconeogenesis	-2.07	1.26e-2	56/67 (83.58%)	ADH7;PGAM1;ALDH1B1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼