Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLNVH8)

Drug Name
TC-2559 Drug Info
Synonyms TC2559
Cross-matching ID
PubChem CID
9823180
ChEBI ID
CHEMBL1876219
TTD Drug ID
D0V0AW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.27 0.00e+0 101/150 (67.33%) HSPA8;HSPA6;PUF60;...
Cell cycle 2.05 2.58e-3 110/124 (88.71%) CDC20;PCNA;CCNB2;...
DNA replication 2.02 1.72e-3 34/36 (94.44%) PCNA;MCM6;RFC3;...
mRNA surveillance pathway 2.00 1.29e-3 71/98 (72.45%) PPP1CC;PELO;PPP2R1B;...
Ribosome biogenesis in eukaryotes 1.98 1.03e-3 52/108 (48.15%) REXO2;NXF3;MPHOSPH10;...
Cytosolic DNA-sensing pathway 1.93 8.60e-4 52/63 (82.54%) CCL5;CCL4;AIM2;...
Oocyte meiosis 1.73 3.39e-2 90/129 (69.77%) CDC20;CCNB2;CCNE2;...
Mismatch repair 1.70 3.29e-2 22/23 (95.65%) PCNA;RFC3;RPA2;...
Graft-versus-host disease 1.65 4.36e-2 32/42 (76.19%) GZMB;PRF1;HLA-DPA1;...
Allograft rejection 1.63 4.80e-2 32/38 (84.21%) GZMB;PRF1;HLA-DPA1;...
Protein digestion and absorption -1.69 4.21e-2 78/103 (75.73%) COL6A3;CELA2B;SLC36A1;...
Glycine, serine and threonine metabolism -1.73 3.23e-2 31/40 (77.5%) SHMT1;CTH;GAMT;...
Focal adhesion -1.75 3.04e-2 180/201 (89.55%) PIK3R2;HRAS;ITGB4;...
Ascorbate and aldarate metabolism -1.76 2.82e-2 15/30 (50%) UGT2B17;ALDH3A2;UGT2B15;...
Bile secretion -1.77 2.46e-2 68/90 (75.56%) BAAT;ADCY8;SCARB1;...
Adherens junction -1.80 2.03e-2 63/71 (88.73%) CSNK2B;PTPRB;IQGAP1;...
AGE-RAGE signaling pathway in diabetic complications -1.81 2.07e-2 97/100 (97%) EGR1;EDN1;SELE;...
Butanoate metabolism -1.89 9.13e-3 23/28 (82.14%) GAD2;GAD1;HMGCS1;...
ECM-receptor interaction -1.89 1.01e-2 80/88 (90.91%) COL4A4;ITGB8;ITGB5;...
Propanoate metabolism -1.90 1.14e-2 30/34 (88.24%) ACACB;DBT;PCCA;...
Steroid biosynthesis -1.91 8.69e-3 19/20 (95%) CYP24A1;EBP;CYP2R1;...
Aldosterone-regulated sodium reabsorption -1.91 7.60e-3 34/37 (91.89%) MAPK3;ATP1B3;HSD11B2;...
PPAR signaling pathway -1.91 9.13e-3 66/74 (89.19%) FABP2;HMGCS1;ACSL1;...
Valine, leucine and isoleucine degradation -2.00 0.00e+0 42/48 (87.5%) BCAT1;ACADM;DBT;...
Proximal tubule bicarbonate reclamation -2.05 0.00e+0 21/23 (91.3%) ATP1B3;ATP1B1;PCK2;...
Phenylalanine metabolism -2.13 0.00e+0 14/17 (82.35%) AOC3;TAT;DDC;...
Mineral absorption -2.55 0.00e+0 48/60 (80%) CYBRD1;ATP7A;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H