Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLOS5R)

Drug Name
BAY 80-6946 Drug Info
Synonyms
Copanlisib; BAY-80-6946; Aliqopa; UNII-WI6V529FZ9; BAY80-6946; WI6V529FZ9; AK172384; BAY 80-6946 (Copanlisib); Copanlisib [USAN:INN]; Copanlisib (USAN/INN); GTPL7875; SCHEMBL1655478; SCHEMBL13084037; Copanlisib (BAY 80-6946); DTXS
Cross-matching ID
PubChem CID
135565596
CAS Number
CAS 1032568-63-0
TTD Drug ID
D0S5LD
INTEDE Drug ID
DR0378
ACDINA Drug ID
D00965

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Basal cell carcinoma -1.67 2.83e-2 41/63 (65.08%) GADD45G;FZD6;TP53;...
PPAR signaling pathway -1.67 2.83e-2 66/74 (89.19%) ACSL3;FABP7;ACSBG1;...
Necroptosis -1.67 2.93e-2 113/159 (71.07%) JAK1;CHMP2A;ALOX15;...
Apoptosis -1.68 2.99e-2 126/168 (75%) CTSD;GADD45G;CAPN1;...
Adipocytokine signaling pathway -1.68 2.72e-2 64/69 (92.75%) TNF;ADIPOQ;SOCS3;...
Sphingolipid metabolism -1.70 2.25e-2 32/49 (65.31%) GLA;ARSA;CERS6;...
Lysosome -1.71 2.16e-2 115/128 (89.84%) ABCB9;AP3M2;ATP6V0D1;...
Mitophagy -1.73 1.63e-2 56/68 (82.35%) TAX1BP1;FOXO3;RAB7A;...
Inflammatory bowel disease -1.73 1.64e-2 58/65 (89.23%) NOD2;NFKB1;FOXP3;...
Type I diabetes mellitus -1.74 1.65e-2 38/43 (88.37%) HSPD1;HLA-G;GAD1;...
Natural killer cell mediated cytotoxicity -1.75 1.37e-2 99/131 (75.57%) GZMB;KLRD1;IFNAR2;...
T cell receptor signaling pathway -1.80 9.10e-3 93/104 (89.42%) PAK2;PLCG1;TNF;...
Cell adhesion molecules -1.82 8.80e-3 118/148 (79.73%) CDH4;CD80;SDC1;...
Legionellosis -1.82 6.78e-3 51/57 (89.47%) HSPA1L;TLR4;CASP7;...
Insulin secretion -1.83 6.30e-3 75/86 (87.21%) ATP1B2;PRKCA;PLCB3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.85 4.80e-3 62/70 (88.57%) PLCG1;CXCR2;PTPN11;...
Kaposi sarcoma-associated herpesvirus infection -1.87 4.12e-3 172/193 (89.12%) TICAM1;TRAF3;TLR3;...
Th17 cell differentiation -1.87 4.43e-3 95/107 (88.79%) PLCG1;STAT1;IL27RA;...
Autoimmune thyroid disease -1.90 3.60e-3 46/53 (86.79%) HLA-G;IL4;IL10;...
IL-17 signaling pathway -1.91 2.62e-3 84/94 (89.36%) CHUK;MAPK9;MMP1;...
Leishmaniasis -1.92 1.44e-3 67/77 (87.01%) TNF;STAT1;EEF1A2;...
Thyroid cancer -1.97 1.60e-3 36/37 (97.3%) GADD45G;HRAS;TP53;...
Antigen processing and presentation -2.00 1.80e-3 60/78 (76.92%) TAPBP;HLA-DOB;HLA-DMB;...
Rheumatoid arthritis -2.01 2.06e-3 78/93 (83.87%) TNFRSF11A;IL11;CD80;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -2.02 0.00e+0 79/89 (88.76%) PLCG1;STAT1;NFKBIB;...
Graft-versus-host disease -2.06 0.00e+0 32/42 (76.19%) KIR2DL3;CD80;FAS;...
Allograft rejection -2.16 0.00e+0 32/38 (84.21%) HLA-G;IL4;IL10;...
NF-kappa B signaling pathway -2.16 0.00e+0 90/104 (86.54%) TRAF5;GADD45G;BIRC2;...
Th1 and Th2 cell differentiation -2.17 0.00e+0 80/92 (86.96%) PLCG1;STAT1;NFKBIB;...
TNF signaling pathway -2.21 0.00e+0 103/112 (91.96%) TNF;SOCS3;EDN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H