Details of the Drug Pharmacogenomic Perturbation Atlas

Quinidine Drug Info

Quinact; Quinaglute; Quinalan; Quinatime; Quindine; Quinicardine; Quinidex; Quinidine sulfate; Quiniduran; Quinora; beta-Quinine; Cardioquin; Chinidin; Chinidine; Cin-Quin; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Conchinin; Conchinine; Conquinine; Duraquin; ITX08688JL; Kinidin; Pitayine; chinidinum; quinidina; quinidine; (+)-Quinidine; (8R,9S)-Quinidine; (9S)-6'-Methoxycinchonan-9-ol; (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol; 56-54-2; CHEBI:28593; CHEMBL1294; MFCD00135581; UNII-ITX08688JL

Cross-matching ID

PubChem CID

441074

ChEBI ID

CHEMBL1294

CAS Number

CAS 56-54-2

INTEDE Drug ID

DR1379

General Information of Drug (ID: DMLPICK)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Staphylococcus aureus infection	2.25	0.00e+0	72/95 (75.79%)	KRT19;KRT13;FCGR2A;...
Asthma	2.10	0.00e+0	25/31 (80.65%)	CD40;HLA-DPB1;HLA-DMB;...
Intestinal immune network for IgA production	2.01	0.00e+0	38/48 (79.17%)	CXCL12;CD40;HLA-DPB1;...
Systemic lupus erythematosus	1.99	0.00e+0	45/135 (33.33%)	CD40;FCGR2A;HLA-DPB1;...
DNA replication	1.93	2.96e-3	34/36 (94.44%)	MCM7;RFC2;RFC5;...
Allograft rejection	1.91	3.70e-3	32/38 (84.21%)	CD40;HLA-DPB1;HLA-DMB;...
Spliceosome	1.84	5.28e-3	101/150 (67.33%)	HSPA6;HSPA1A;HNRNPA1;...
Leishmaniasis	1.84	4.62e-3	67/77 (87.01%)	EEF1A2;MARCKSL1;FCGR2A;...
Homologous recombination	1.84	4.11e-3	35/41 (85.37%)	RBBP8;RAD54B;BARD1;...
Mismatch repair	1.81	4.44e-3	22/23 (95.65%)	RFC2;RFC5;EXO1;...
Antigen processing and presentation	1.75	1.41e-2	60/78 (76.92%)	HSPA6;HSPA1A;IFI30;...
Autoimmune thyroid disease	1.74	1.36e-2	46/53 (86.79%)	CD40;HLA-DPB1;HLA-DMB;...
Glyoxylate and dicarboxylate metabolism	1.73	1.65e-2	23/30 (76.67%)	GLUL;DLD;SHMT2;...
Cell cycle	1.71	2.22e-2	110/124 (88.71%)	CCNB2;CDC25A;MCM7;...
Fructose and mannose metabolism	1.69	2.56e-2	30/33 (90.91%)	TPI1;AKR1B10;PFKFB3;...
Base excision repair	1.68	2.50e-2	29/33 (87.88%)	POLE2;POLD2;SMUG1;...
Rheumatoid arthritis	1.62	4.92e-2	78/93 (83.87%)	CXCL12;CCL2;ACP5;...
RNA degradation	1.62	4.85e-2	53/79 (67.09%)	PAN2;EXOSC4;ENO3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H