Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLQO7F)

Drug Name
EVP-6124 Drug Info
Synonyms
Encenicline; EVP-6124; 550999-75-2; UNII-5FI5376A0X; EVP6124; EVP 6124; CHEMBL2151572; (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide; 5FI5376A0X; C16H17ClN2OS; 550999-74-1; Encenicline [USAN:INN]; FRM-6124; Encenicline (USAN/INN); SCHEMBL744767; GTPL6926; SSRDSYXGYPJKRR-ZDUSSCGKSA-N; ZINC95579362; BDBM50393255; 3662AH; AKOS027322165; DB11726; CS-0933; MT-4666; Benzo(b)thiophene-2-carboxamide, N-(3R)-1-azabicyclo(2.2.2)oct-3-yl-7-chloro-; NCGC00378871-01; HY-15430; W-5978; D10626
Cross-matching ID
PubChem CID
46196517
ChEBI ID
CHEMBL2151572
CAS Number
CAS 550999-75-2
TTD Drug ID
D0D3TX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Terpenoid backbone biosynthesis 2.18 0.00e+0 18/22 (81.82%) ACAT2;IDI1;HMGCR;...
Retinol metabolism 2.18 0.00e+0 41/68 (60.29%) ADH5;CYP3A4;UGT2B28;...
Steroid biosynthesis 2.16 0.00e+0 19/20 (95%) SC5D;DHCR7;DHCR24;...
Bile secretion 2.14 0.00e+0 68/90 (75.56%) GNAS;CYP3A4;UGT2B28;...
Drug metabolism 2.08 0.00e+0 78/151 (51.66%) ADH5;CYP3A4;UGT2B28;...
Metabolism of xenobiotics by cytochrome P450 1.97 0.00e+0 49/77 (63.64%) ADH5;CYP3A4;UGT2B28;...
Complement and coagulation cascades 1.96 1.04e-3 76/85 (89.41%) PLAT;F12;SERPINA1;...
Pyruvate metabolism 1.86 2.74e-3 41/47 (87.23%) ACAT2;ADH5;ADH1C;...
Biosynthesis of unsaturated fatty acids 1.85 4.05e-3 21/27 (77.78%) SCD;FADS2;ELOVL1;...
PPAR signaling pathway 1.84 3.65e-3 66/74 (89.19%) SCD;PLIN2;FADS2;...
Ascorbate and aldarate metabolism 1.75 1.59e-2 15/30 (50%) UGT2B28;UGT2A3;UGT2B15;...
Fatty acid degradation 1.72 1.89e-2 40/43 (93.02%) ACAT2;ADH5;ACSL1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.68 3.20e-2 9/11 (81.82%) HPD;COQ2;GGCX;...
Mucin type O-glycan biosynthesis 1.67 3.39e-2 20/36 (55.56%) GALNT10;GALNT6;GALNT7;...
Cholesterol metabolism 1.67 3.16e-2 44/50 (88%) NPC2;ANGPTL3;CYP27A1;...
Glyoxylate and dicarboxylate metabolism 1.66 3.33e-2 23/30 (76.67%) ACAT2;SHMT1;HAO1;...
Nitrogen metabolism -1.64 4.03e-2 16/17 (94.12%) CA6;CPS1;CA2;...
Colorectal cancer -1.64 4.21e-2 84/86 (97.67%) PIK3CA;MSH3;SOS2;...
Cushing syndrome -1.67 3.32e-2 125/155 (80.65%) MAP2K2;PLCB3;CACNA1H;...
African trypanosomiasis -1.67 3.47e-2 32/37 (86.49%) VCAM1;FAS;IFNG;...
VEGF signaling pathway -1.68 3.45e-2 50/59 (84.75%) SH2D2A;RAC2;NOS3;...
cGMP-PKG signaling pathway -1.69 3.49e-2 145/167 (86.83%) PPP3CB;CALML4;MAP2K2;...
Thyroid cancer -1.69 3.68e-2 36/37 (97.3%) CDH1;TCF7;PPARG;...
Graft-versus-host disease -1.71 3.59e-2 32/42 (76.19%) HLA-DMB;FAS;IFNG;...
Th1 and Th2 cell differentiation -1.74 2.74e-2 80/92 (86.96%) TYK2;PPP3CB;JAK1;...
AGE-RAGE signaling pathway in diabetic complications -1.74 2.83e-2 97/100 (97%) VCAM1;AGTR1;JUN;...
Prostate cancer -1.76 2.75e-2 93/97 (95.88%) CASP9;PDGFB;IGF1R;...
Chronic myeloid leukemia -1.76 2.96e-2 72/76 (94.74%) NFKBIA;PTPN11;PIK3CA;...
Pancreatic cancer -1.76 3.09e-2 75/76 (98.68%) BCL2L1;DDB2;RALGDS;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.78 2.65e-2 79/89 (88.76%) NFKBIA;PTPN11;PIK3CA;...
Glioma -1.79 2.39e-2 67/75 (89.33%) PIK3CA;PDGFRB;SOS2;...
Bladder cancer -1.79 2.65e-2 40/41 (97.56%) CDH1;FGFR3;KRAS;...
Hematopoietic cell lineage -1.86 1.16e-2 90/99 (90.91%) CR1;HLA-DOA;CD4;...
T cell receptor signaling pathway -1.90 9.47e-3 93/104 (89.42%) NFKBIA;PIK3CA;SOS2;...
IL-17 signaling pathway -1.90 8.84e-3 84/94 (89.36%) IKBKE;MMP1;IL17RA;...
Kaposi sarcoma-associated herpesvirus infection -1.95 5.31e-3 172/193 (89.12%) CSF2;CASP9;PDGFB;...
Breast cancer -1.97 6.63e-3 119/147 (80.95%) SHC3;MAP2K2;FGF7;...
Rheumatoid arthritis -2.00 0.00e+0 78/93 (83.87%) FLT1;IL18;HLA-DOA;...
Primary immunodeficiency -2.03 0.00e+0 33/38 (86.84%) RFX5;CD4;ZAP70;...
TNF signaling pathway -2.11 0.00e+0 103/112 (91.96%) CSF2;SOCS3;VCAM1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H