Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLRQH0)

Drug Name
Indirubin-3'-monoxime Drug Info
Synonyms
INDIRUBIN-3'-MONOXIME; indirubin-3'-oxime; 160807-49-8; indirubin-3-oxime; Indirubin-3monoxime; Indirubin-3-monoxime; 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one; CHEBI:43645; Indirubin 3'-monoxime; indirubin-3'-monooxime; Indirubin-3& CHEMBL216543; CHEMBL126077; (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME; UNM-0000305771; 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; 667463-82-3; IXM; SR-01000075929; Indirubin-3; Indirubin 3-oxime; Tocris-1813; BiomolKI_000070; Indirubin-3-oxime
Cross-matching ID
PubChem CID
3707
ChEBI ID
CHEMBL43645
CAS Number
CAS 160807-49-8
TTD Drug ID
D0Y0ES

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.21 0.00e+0 113/158 (71.52%) MRPS2;RSL24D1;RPL10;...
Ferroptosis 2.04 3.44e-3 36/41 (87.8%) SLC7A11;SLC39A14;SLC3A2;...
RNA polymerase 1.88 1.61e-2 23/31 (74.19%) POLR2I;POLR1C;POLR3D;...
RNA transport 1.88 1.20e-2 128/186 (68.82%) EIF4EBP1;CLNS1A;EIF2S3;...
Ribosome biogenesis in eukaryotes 1.87 1.10e-2 52/108 (48.15%) EIF6;IMP4;DKC1;...
Protein processing in endoplasmic reticulum 1.85 9.18e-3 127/171 (74.27%) HERPUD1;HSPA5;DDIT3;...
Proteasome 1.78 2.16e-2 44/46 (95.65%) PSMD14;PSMD2;PSMD6;...
Folate biosynthesis 1.77 2.07e-2 23/26 (88.46%) AKR1B10;AKR1C3;MOCOS;...
Alanine, aspartate and glutamate metabolism 1.71 3.14e-2 27/37 (72.97%) ASNS;CAD;GOT1;...
Glycine, serine and threonine metabolism 1.68 3.44e-2 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.65 4.32e-2 20/26 (76.92%) PIGG;PIGO;PIGT;...
Cysteine and methionine metabolism 1.64 4.07e-2 43/50 (86%) PSAT1;PHGDH;CBS;...
Mannose type O-glycan biosynthesis 1.64 4.03e-2 14/23 (60.87%) RXYLT1;FKTN;POMGNT1;...
ECM-receptor interaction -1.86 4.38e-2 80/88 (90.91%) SDC4;LAMA4;ITGA5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H