Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLSEJN)

Drug Name
Monastrol Drug Info
Synonyms
monastrol; 329689-23-8; 254753-54-3; ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE; 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester; CHEBI:75382; ( inverted exclamation markA)-Monastrol; SR-01000357662; AC1MGLGQ; Probes2_000257; Probes2_000376; Probes1_000312; Probes1_000042; Probes1_000001; Oprea1_487786; Lopac0_000821; KBioSS_000613; CBDivE_015834; KBioGR_000613; BSPBio_001273; MLS006011746; SCHEMBL3168349; KBio3_001085; KBio2_000613
Cross-matching ID
PubChem CID
2987927
ChEBI ID
CHEMBL236789
CAS Number
CAS 329689-23-8
TTD Drug ID
D0ZK2G

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Parkinson disease 1.91 2.46e-2 176/249 (70.68%) SLC25A6;PRKACB;TXN;...
Folate biosynthesis 1.88 1.23e-2 23/26 (88.46%) AKR1C3;AKR1B10;MOCS2;...
TGF-beta signaling pathway 1.86 1.23e-2 81/94 (86.17%) ID1;ID2;ID3;...
Hepatocellular carcinoma 1.84 1.23e-2 135/168 (80.36%) HMOX1;NQO1;WNT5A;...
Citrate cycle (TCA cycle) 1.77 3.20e-2 30/30 (100%) PCK2;SDHD;DLD;...
Tryptophan metabolism 1.77 2.67e-2 35/42 (83.33%) CYP1B1;AOC1;EHHADH;...
Oxidative phosphorylation 1.74 4.39e-2 93/133 (69.92%) NDUFS6;NDUFS7;ATP5MC2;...
Fatty acid elongation 1.73 4.61e-2 19/27 (70.37%) TECR;ACAA2;ACOT7;...
Proximal tubule bicarbonate reclamation 1.72 4.24e-2 21/23 (91.3%) PCK2;CA2;FXYD2;...
Wnt signaling pathway 1.70 4.80e-2 124/166 (74.7%) WNT5A;DKK1;BAMBI;...
PPAR signaling pathway -1.59 4.65e-2 66/74 (89.19%) RXRB;ACADM;PLIN2;...
Purine metabolism -1.59 4.45e-2 102/129 (79.07%) ENPP1;RRM2;PKM;...
Vibrio cholerae infection -1.61 4.01e-2 44/50 (88%) ATP6V0A1;ATP6V1A;SLC12A2;...
Rheumatoid arthritis -1.61 4.00e-2 78/93 (83.87%) HLA-DMB;ATP6V0A1;ATP6V1A;...
Protein export -1.63 3.33e-2 17/23 (73.91%) SPCS3;SEC61A1;SRPRA;...
Malaria -1.63 3.37e-2 44/50 (88%) TLR2;ICAM1;COMP;...
Viral protein interaction with cytokine and cytokine re... -1.64 3.19e-2 84/100 (84%) TNFSF14;CXCL9;IL6ST;...
Cholesterol metabolism -1.65 2.89e-2 44/50 (88%) APOA1;APOE;LCAT;...
Circadian rhythm -1.65 2.96e-2 26/31 (83.87%) PER1;NPAS2;BHLHE41;...
Herpes simplex virus 1 infection -1.66 2.72e-2 165/498 (33.13%) EIF2B1;IKBKB;SRPK1;...
Legionellosis -1.75 1.43e-2 51/57 (89.47%) NFKB1;ARF1;CYCS;...
Leishmaniasis -1.75 1.54e-2 67/77 (87.01%) NCF2;MAPK13;FCGR3B;...
Amino sugar and nucleotide sugar metabolism -1.75 1.59e-2 38/48 (79.17%) GNE;HK1;CHIT1;...
Various types of N-glycan biosynthesis -1.76 1.74e-2 26/39 (66.67%) B4GALT1;B4GALT2;MGAT2;...
Other glycan degradation -1.76 1.91e-2 13/18 (72.22%) GLB1;MANBA;NEU1;...
N-Glycan biosynthesis -1.77 1.85e-2 38/50 (76%) B4GALT1;GANAB;B4GALT2;...
NF-kappa B signaling pathway -1.82 1.35e-2 90/104 (86.54%) TAB2;TNFSF14;NFKB1;...
TNF signaling pathway -1.85 8.32e-3 103/112 (91.96%) CREB3;SOCS3;PIK3CB;...
Systemic lupus erythematosus -1.92 4.16e-3 45/135 (33.33%) FCGR3B;HLA-DMB;C5;...
Pertussis -1.92 3.33e-3 64/76 (84.21%) NLRP3;MAPK13;GNAI1;...
Phagosome -1.94 4.16e-3 118/152 (77.63%) FCGR3B;HLA-DMB;SCARB1;...
Staphylococcus aureus infection -1.95 5.55e-3 72/95 (75.79%) FCGR3B;FPR3;HLA-DMB;...
IL-17 signaling pathway -1.97 4.16e-3 84/94 (89.36%) IL1B;MAP3K7;HSP90B1;...
Complement and coagulation cascades -2.15 0.00e+0 76/85 (89.41%) C1QB;TFPI;CFHR2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H