Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLVSYX)

Drug Name
Remimazolam Drug Info
Synonyms
CNS-7054; CNS-7056; CNS-7056B; CNS-7056X; GW-351564X; GW-418259X; GW-457837A; GW-502056X; ONO-2745; Short-acting sedatives, Therasci; GABA A agonist (anesthesia, sedation) CeNeS/Ono; Sedatives (short acting), CeNeS/Ono; Sedatives (short acting), PAION/Ono; Sedatives (short-acting), TheraSci; Short-acting sedatives, Therasci/GSK; Sedatives (short-acting), TheraSci/GSK
Cross-matching ID
PubChem CID
9867812
CAS Number
CAS 308242-62-8
TTD Drug ID
D0L5KU
ACDINA Drug ID
D01382

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 1.91 6.30e-2 113/158 (71.52%) RPS4Y1;RPS5;RPL36;...
Aminoacyl-tRNA biosynthesis 1.65 2.49e-1 15/66 (22.73%) NARS2;TARS2;QRSL1
Proteasome 1.50 6.21e-1 44/46 (95.65%) PSME4;PSME3;PSMF1;...
Terpenoid backbone biosynthesis 1.47 5.68e-1 18/22 (81.82%) ACAT2;HMGCS2;IDI1;...
Homologous recombination 1.46 4.89e-1 35/41 (85.37%) BRCA1;BRCC3;RPA2;...
Pancreatic secretion 1.43 5.10e-1 87/102 (85.29%) PRKCA;CPB1;PRSS1;...
GnRH secretion 1.35 8.11e-1 60/64 (93.75%) PRKCA;KCNN2;GNA11;...
Hypertrophic cardiomyopathy 1.20 7.92e-1 81/90 (90%) ITGAV;TNNC1;TGFB2;...
Cysteine and methionine metabolism 1.20 7.71e-1 43/50 (86%) BCAT1;CBS;PSAT1;...
Cellular senescence 1.19 7.65e-1 139/156 (89.1%) CCNA1;MYBL2;RAD1;...
Glyoxylate and dicarboxylate metabolism 1.18 7.58e-1 23/30 (76.67%) DLD;PCCB;ACAT2
Mismatch repair 1.18 7.34e-1 22/23 (95.65%) LIG1;RPA2;RFC2;...
Valine, leucine and isoleucine degradation 1.18 7.21e-1 42/48 (87.5%) DLD;PCCB;ACAD8;...
Leishmaniasis 1.16 7.72e-1 67/77 (87.01%) EEF1A2;HLA-DQB1;STAT1;...
Riboflavin metabolism 1.15 7.92e-1 7/8 (87.5%) BLVRB;ENPP1;RFK
Synthesis and degradation of ketone bodies 1.11 7.96e-1 9/10 (90%) ACAT2;HMGCS2;HMGCS1
Circadian rhythm 1.11 7.83e-1 26/31 (83.87%) PER1;RBX1;RORA;...
Arrhythmogenic right ventricular cardiomyopathy 1.11 7.60e-1 70/77 (90.91%) ITGAV;LEF1;GJA1;...
Parathyroid hormone synthesis, secretion and action 1.09 8.01e-1 98/106 (92.45%) PRKCA;PDE4A;CYP27B1;...
Bacterial invasion of epithelial cells 1.09 7.96e-1 59/77 (76.62%) CRK;PXN;CTNNA2;...
Rap1 signaling pathway 1.09 7.99e-1 184/210 (87.62%) PDGFC;PRKCA;CTNND1;...
Propanoate metabolism 1.08 8.13e-1 30/34 (88.24%) DLD;PCCB;ACACA;...
Coronavirus disease 1.07 8.02e-1 215/232 (92.67%) RPS4Y1;CXCL10;PRKCA;...
Steroid biosynthesis 1.07 8.01e-1 19/20 (95%) CYP27B1;TM7SF2;FDFT1;...
Toll-like receptor signaling pathway 1.02 8.15e-1 94/104 (90.38%) CXCL10;CD14;CXCL9;...
Progesterone-mediated oocyte maturation 1.02 8.13e-1 75/100 (75%) CCNA1;GNAI1;ADCY2;...
Regulation of actin cytoskeleton 1.01 8.15e-1 185/218 (84.86%) PDGFC;ITGAV;CXCR4;...
Starch and sucrose metabolism 1.00 8.09e-1 25/36 (69.44%) GBE1;G6PC3;ENPP1;...
Central carbon metabolism in cancer 0.99 8.09e-1 67/70 (95.71%) ERBB2;SLC7A5;SLC1A5;...
Cell cycle 0.99 8.14e-1 110/124 (88.71%) CCNA1;ORC1;SMC3;...
Osteoclast differentiation -1.23 4.80e-1 117/127 (92.13%) NCF4;MAPK8;PPP3R1;...
Protein digestion and absorption -1.23 4.81e-1 78/103 (75.73%) SLC7A7;ACE2;COL9A2;...
JAK-STAT signaling pathway -1.23 4.86e-1 146/162 (90.12%) SOCS5;CDKN1A;IL6;...
Vibrio cholerae infection -1.33 4.78e-1 44/50 (88%) SEC61B;TJP1;GNAS;...
Graft-versus-host disease -1.33 4.63e-1 32/42 (76.19%) HLA-A;PRF1;IL1B;...
beta-Alanine metabolism -1.33 4.76e-1 25/30 (83.33%) CNDP2;HIBCH;ACOX3;...
Glycerolipid metabolism -1.34 4.82e-1 44/61 (72.13%) DGAT1;PNPLA2;PLPP2;...
D-Glutamine and D-glutamate metabolism -1.34 4.82e-1 5/5 (100%) GLS;GLS2;GLUD2;...
Natural killer cell mediated cytotoxicity -1.35 4.73e-1 99/131 (75.57%) SH2D1A;NRAS;PRKCB;...
Chronic myeloid leukemia -1.35 4.56e-1 72/76 (94.74%) CDKN1A;HDAC1;MDM2;...
African trypanosomiasis -1.36 4.66e-1 32/37 (86.49%) PRKCB;LAMA4;HBB;...
Ascorbate and aldarate metabolism -1.36 4.76e-1 15/30 (50%) UGT2A3;UGT2B28;GUSB;...
Renin-angiotensin system -1.37 4.79e-1 20/23 (86.96%) CTSA;ACE2;MME;...
TGF-beta signaling pathway -1.38 4.77e-1 81/94 (86.17%) TGFBR2;BMPR1B;SKP1;...
Protein processing in endoplasmic reticulum -1.42 4.42e-1 127/171 (74.27%) MAPK10;GANAB;RPN2;...
Primary bile acid biosynthesis -1.42 4.62e-1 15/17 (88.24%) CYP46A1;CYP7B1;SCP2;...
Proximal tubule bicarbonate reclamation -1.44 4.61e-1 21/23 (91.3%) SLC25A10;ATP1B1;MDH1;...
Antigen processing and presentation -1.45 4.47e-1 60/78 (76.92%) NFYB;CD8A;HSPA1L;...
p53 signaling pathway -1.46 4.33e-1 63/73 (86.3%) MDM4;CDK2;CASP3;...
Tyrosine metabolism -1.47 4.64e-1 30/36 (83.33%) COMT;PNMT;ADH1B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.47 4.84e-1 62/70 (88.57%) TJP1;MAPK8;CXCR2;...
Rheumatoid arthritis -1.49 4.66e-1 78/93 (83.87%) ATP6V1H;IL1B;FOS;...
Lipid and atherosclerosis -1.50 4.67e-1 190/215 (88.37%) CHUK;TNFSF10;LYN;...
Phenylalanine metabolism -1.52 4.51e-1 14/17 (82.35%) GOT1;MIF;AOC3;...
Renin secretion -1.53 4.74e-1 61/69 (88.41%) KCNJ2;PDE3B;AGT;...
Apoptosis -1.58 4.12e-1 126/168 (75%) TNFRSF1A;CASP6;IL3RA;...
Glioma -1.60 4.33e-1 67/75 (89.33%) MDM2;CCND1;DDB2;...
Measles -1.63 4.10e-1 133/139 (95.68%) CDK4;IL2RB;CHUK;...
NF-kappa B signaling pathway -1.66 4.43e-1 90/104 (86.54%) PIDD1;BCL2A1;LTA;...
PPAR signaling pathway -1.77 2.51e-1 66/74 (89.19%) PPARG;APOC3;SCP2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H