Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMLYZOG)

Drug Name
NORBINALTORPHIMINE Drug Info
Synonyms
Norbinaltorphimine; nor-Binaltorphimine; UNII-36OOQ86QM1; 36OOQ86QM1; CHEBI:81529; C18130; 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-20-methyl-, (8R-(4bR*,8alpha,8abeta,10aalpha,11beta,14aR*,19aalpha,20bbeta))-; Nor-Binaltorphamine; (-)-norbinaltorphimine; NOR-BNI (HCI)2; Lopac0_000806; GTPL1642; CHEMBL573214; SCHEMBL12013206; BDBM82551; APSUXPSYBJVPPS-YAUKWVCOSA-N
Cross-matching ID
PubChem CID
5480230
ChEBI ID
CHEMBL573214
CAS Number
CAS 105618-26-6
TTD Drug ID
D05QJS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral protein interaction with cytokine and cytokine re... 2.16 0.00e+0 84/100 (84%) TNFSF10;CXCL5;IL18;...
Sulfur metabolism -1.78 3.61e-2 9/10 (90%) TST;ETHE1;MPST;...
Glycolysis / Gluconeogenesis -1.81 3.28e-2 56/67 (83.58%) ALDH3B1;PKM;PFKP;...
TGF-beta signaling pathway -1.84 2.46e-2 81/94 (86.17%) BMP2;GDF5;MAPK3;...
Nicotinate and nicotinamide metabolism -1.87 1.23e-2 25/35 (71.43%) NT5C2;SIRT5;SIRT7;...
Glycine, serine and threonine metabolism -1.87 2.46e-2 31/40 (77.5%) DLD;ALAS1;PIPOX;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H