Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM0PDO)

Drug Name
Dalfampridine Drug Info
Synonyms Ampyra (TN)
Cross-matching ID
PubChem CID
1727
ChEBI ID
CHEMBL284348
CAS Number
CAS 504-24-5
TTD Drug ID
D08YIN
INTEDE Drug ID
DR0408
ACDINA Drug ID
D00001

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.14 0.00e+0 113/158 (71.52%) RPS5;RPL13;RPL29;...
IL-17 signaling pathway 2.07 0.00e+0 84/94 (89.36%) CXCL5;CXCL8;TNFAIP3;...
Proteasome 2.04 0.00e+0 44/46 (95.65%) PSMB8;PSME1;PSMB9;...
Oxidative phosphorylation 2.01 0.00e+0 93/133 (69.92%) COX6B1;ATP5F1C;NDUFAB1;...
Parkinson disease 1.90 2.11e-3 176/249 (70.68%) TUBB2A;COX6B1;PRKACB;...
Non-alcoholic fatty liver disease 1.85 3.52e-3 126/155 (81.29%) CXCL8;CDC42;COX6B1;...
Prion disease 1.84 3.02e-3 209/273 (76.56%) TUBB2A;NOTCH1;COX6B1;...
Huntington disease 1.80 1.98e-2 233/306 (76.14%) TUBB2A;COX6B1;ATP5F1C;...
Viral carcinogenesis 1.73 3.76e-2 149/203 (73.4%) SRC;CDC42;KRAS;...
Coronavirus disease 1.72 3.70e-2 215/232 (92.67%) CXCL8;RPS5;RPL13;...
Rheumatoid arthritis 1.72 3.46e-2 78/93 (83.87%) CXCL5;CXCL8;ANGPT1;...
Legionellosis 1.70 3.79e-2 51/57 (89.47%) CXCL8;CASP7;CYCS;...
Nucleotide excision repair 1.70 3.50e-2 40/47 (85.11%) RPA3;CCNH;RAD23B;...
p53 signaling pathway 1.68 4.53e-2 63/73 (86.3%) IGFBP3;CCNB1;CHEK1;...
Arginine biosynthesis -1.91 1.40e-2 17/22 (77.27%) ARG1;GLS2;NOS3;...
Glycerophospholipid metabolism -1.94 2.79e-2 71/98 (72.45%) GNPAT;ETNK2;AGPAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM 24H