Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM2I9G)

Drug Name
ischemin Drug Info
Synonyms MS120
Cross-matching ID
PubChem CID
135566302
ChEBI ID
CHEMBL95084
TTD Drug ID
D00DXI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.30 0.00e+0 34/36 (94.44%) PCNA;MCM4;POLE2;...
Spliceosome 1.91 1.48e-2 101/150 (67.33%) LSM5;SNRPG;SNRPD1;...
Cell cycle 1.88 9.89e-3 110/124 (88.71%) CCNE2;PCNA;CDC20;...
Fanconi anemia pathway 1.85 1.11e-2 36/54 (66.67%) USP1;RMI1;BRCA1;...
Base excision repair 1.72 4.30e-2 29/33 (87.88%) PCNA;POLE2;FEN1;...
Hematopoietic cell lineage -1.64 4.88e-2 90/99 (90.91%) ITGB3;IL2RA;IL6;...
Viral protein interaction with cytokine and cytokine re... -1.65 4.71e-2 84/100 (84%) IL24;CCL22;CX3CL1;...
Mitophagy -1.67 4.05e-2 56/68 (82.35%) CALCOCO2;BNIP3L;MITF;...
Glycerolipid metabolism -1.70 2.71e-2 44/61 (72.13%) PLPP2;ALDH3A2;AKR1A1;...
Antigen processing and presentation -1.70 2.73e-2 60/78 (76.92%) CIITA;NFYA;HLA-G;...
Primary immunodeficiency -1.70 2.74e-2 33/38 (86.84%) CD4;CD40LG;RFX5;...
T cell receptor signaling pathway -1.71 2.69e-2 93/104 (89.42%) PAK6;CSF2;PAK4;...
Rheumatoid arthritis -1.73 2.08e-2 78/93 (83.87%) CD80;IL23A;TNFSF13;...
Cell adhesion molecules -1.74 2.22e-2 118/148 (79.73%) CLDN6;SELPLG;CLDN4;...
Lysosome -1.75 1.94e-2 115/128 (89.84%) AP1G2;CTNS;NPC1;...
Natural killer cell mediated cytotoxicity -1.81 7.59e-3 99/131 (75.57%) PLCG2;PLCG1;CSF2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.82 8.23e-3 62/70 (88.57%) PLCG2;PLCG1;NFKBIA;...
IL-17 signaling pathway -1.83 8.97e-3 84/94 (89.36%) CSF2;NFKBIA;S100A8;...
NF-kappa B signaling pathway -1.83 8.64e-3 90/104 (86.54%) CYLD;BTK;PLCG2;...
Pentose and glucuronate interconversions -1.83 9.60e-3 17/34 (50%) SORD;AKR1A1;UGDH;...
Intestinal immune network for IgA production -1.86 9.25e-3 38/48 (79.17%) CD28;IL5;CCL25;...
Type I diabetes mellitus -1.91 3.53e-3 38/43 (88.37%) CD28;HLA-DRB1;IL1A;...
Th17 cell differentiation -1.96 4.11e-3 95/107 (88.79%) STAT5A;IL2RA;IL6;...
Ferroptosis -2.01 0.00e+0 36/41 (87.8%) MAP1LC3B;CP;PCBP2;...
Th1 and Th2 cell differentiation -2.06 0.00e+0 80/92 (86.96%) STAT5A;IL2RA;HLA-DPA1;...
Autoimmune thyroid disease -2.08 0.00e+0 46/53 (86.79%) FAS;CD40LG;TSHR;...
Allograft rejection -2.15 0.00e+0 32/38 (84.21%) FAS;CD40LG;CD28;...
Graft-versus-host disease -2.16 0.00e+0 32/42 (76.19%) CD28;KIR3DL1;HLA-DRB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H