Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM4WBX)

Drug Name
Methocarbamol Drug Info
Synonyms
methocarbamol; 532-03-6; Robaxin; Metocarbamol; Metocarbamolo; Lumirelax; Parabaxin; Relestrid; Myolaxene; Miolaxene; Metofenia; Miorilas; Surquetil; Reflexyn; Neuraxin; Methocal; Tresortil; Romethocarb; Etroflex; Miowas; Perilax; Delaxin; Avetil; Robinax; Metofenina; Guaiacol glyceryl ether carbamate; Guaiphenesin carbamate; Guaiphenesine carbamate; Glycerylguaiacolate carbamate; Glycerylguajacol-carbamat; Methocarbamolum; Forbaxin; 2-Hydroxy-3-(2-methoxyphenoxy)propyl carbamate; AHR 85; Robaxine; Robamol; Traumacut; Robaxon; Robaxan
Cross-matching ID
PubChem CID
4107
ChEBI ID
CHEMBL1201117
CAS Number
CAS 532-03-6
TTD Drug ID
D0FN7J

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway -1.72 4.62e-2 90/104 (86.54%) GADD45A;ERC1;TLR4;...
Vibrio cholerae infection -1.73 4.47e-2 44/50 (88%) KCNQ1;ATP6V0E1;ATP6V0B;...
Cardiac muscle contraction -1.74 4.78e-2 64/87 (73.56%) ACTC1;COX7B;CYC1;...
Graft-versus-host disease -1.75 4.62e-2 32/42 (76.19%) IL1A;HLA-DRB1;GZMB;...
Epithelial cell signaling in Helicobacter pylori infect... -1.96 6.93e-3 62/70 (88.57%) PAK1;ATP6V0E1;ATP6V0B;...
Primary immunodeficiency -1.98 5.77e-3 33/38 (86.84%) ZAP70;CD8A;ADA;...
Oxidative phosphorylation -2.05 0.00e+0 93/133 (69.92%) ATP5MG;NDUFS7;SDHC;...
Rheumatoid arthritis -2.08 0.00e+0 78/93 (83.87%) CD80;TEK;ATP6V1E1;...
IL-17 signaling pathway -2.24 0.00e+0 84/94 (89.36%) MMP9;DEFB4A;TRAF5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H