Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM75WZ)

• Drug Name: Chloroxylenol Drug Info
• Synonyms: Benzytol; Chloro-xylenol; Chloroxylenolum; Chlorxylenolum; Clorossilenolo; Cloroxilenol; Desson; Dettol; Dettol, liquid antiseptic; Espadol; Husept Extra; Nipacide MX; Ottasept; Ottasept Extra; Parametaxylenol; Phenol, 4-chloro-3,5-dimethyl-; RBA 777; Septiderm-Hydrochloride; Willenol V; chloroxylenol; p-Chloro-3,5-xylenol; p-Chloro-m-xylenol; parachlorometaxylenol; 2-Chloro-5-hydroxy-m-xylene; 2-Chloro-m-xylenol; 3,5-Dimethyl-4-chlorophenol; 4-Chloro-3,5-dimethylphenol; 4-Chloro-3,5-xylenol; 4-Chloro-m-xylenol; 88-04-0; PCMX
• Cross-matching ID:
  PubChem CID: 2723
  ChEBI ID: CHEMBL398440
  CAS Number: CAS 88-04-0
  INTEDE Drug ID: DR0302

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Parkinson disease	-1.67	4.90e-2	176/249 (70.68%)	EIF2AK3;COX6C;ATP5MC3;...
Non-alcoholic fatty liver disease	-1.73	3.90e-2	126/155 (81.29%)	MAP3K11;CXCL8;NDUFB1;...
Hematopoietic cell lineage	-1.73	4.33e-2	90/99 (90.91%)	CD3G;IL1R1;CSF1R;...
Morphine addiction	-1.73	4.44e-2	80/91 (87.91%)	GABRA2;GNAI3;GNG12;...
Retrograde endocannabinoid signaling	-1.77	2.95e-2	118/148 (79.73%)	NDUFB1;NDUFB3;GABRA2;...
Vibrio cholerae infection	-1.78	3.06e-2	44/50 (88%)	TJP1;ATP6V1H;KDELR2;...
RNA polymerase	-1.80	2.75e-2	23/31 (74.19%)	POLR2L;POLR2G;POLR2F;...
Thermogenesis	-1.86	8.60e-3	173/232 (74.57%)	BMP8A;PRKAA1;COX7A1;...
Collecting duct acid secretion	-2.01	0.00e+0	22/27 (81.48%)	ATP6V0E2;ATP4B;ATP6V0A4;...
Proximal tubule bicarbonate reclamation	-2.10	0.00e+0	21/23 (91.3%)	MDH1;FXYD2;AQP1;...
Oxidative phosphorylation	-2.29	0.00e+0	93/133 (69.92%)	ATP5F1C;ATP5ME;ATP6V1H;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲