Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMM7DHB)

Drug Name
3-bromo-7-nitro-1H-indazole Drug Info
Synonyms
3-Bromo-7-nitroindazole; 3-Bromo-7-nitro-1H-indazole; 3-bromo-7-nitroindazole; 74209-34-0; 1H-Indazole,3-bromo-7-nitro-; 3-bromo-7-nitro-2H-indazole; CHEMBL479014; NFSTZPMYAZRZPC-UHFFFAOYSA-N; MFCD00159910; AK-27879; SR-01000075708; 3-bromo-7NI; Tocris-0735; 3-Br-7-Nitroindazole; AC1L1BXC; Lopac-B-2050; 3-Br-7NI; Lopac0_000161; BSPBio_002434; BSPBio_001502; KBioGR_000222; KBioSS_000222; SPECTRUM1505105; SCHEMBL499422; SCHEMBL499421; GTPL5113; KBio3_000444; KBio3_000443; KBio2_002790; CTK5D9545; BCBcMAP01_000129; KBio2_005358; KBio2_000222; DTXSID90274319; OR6862T; 3-Bromo-7-Nitroindazole
Cross-matching ID
PubChem CID
1649
ChEBI ID
CHEMBL479014
CAS Number
CAS 74209-34-0
TTD Drug ID
D0X5QJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 2.24 0.00e+0 25/31 (80.65%) HLA-DRA;HLA-DRB1;PRG2;...
Parkinson disease 2.14 4.88e-3 176/249 (70.68%) NDUFS4;DUSP1;NFE2L2;...
Ribosome 2.12 3.26e-3 113/158 (71.52%) MRPL35;RSL24D1;RPS26;...
Oxidative phosphorylation 2.09 2.44e-3 93/133 (69.92%) NDUFS4;NDUFB5;COX7A2L;...
Proteasome 2.05 1.95e-3 44/46 (95.65%) PSMD3;PSMA1;PSMA2;...
Antigen processing and presentation 1.99 3.26e-3 60/78 (76.92%) NFYA;HLA-DRA;HLA-DRB1;...
Spliceosome 1.95 2.79e-3 101/150 (67.33%) SRSF1;MAGOH;SRSF10;...
Intestinal immune network for IgA production 1.95 2.44e-3 38/48 (79.17%) HLA-DRA;HLA-DRB1;CXCL12;...
Systemic lupus erythematosus 1.94 2.17e-3 45/135 (33.33%) HLA-DRA;ELANE;HLA-DRB1;...
Allograft rejection 1.81 1.37e-2 32/38 (84.21%) HLA-DRA;HLA-DRB1;HLA-DPA1;...
Complement and coagulation cascades 1.81 1.51e-2 76/85 (89.41%) SERPING1;SERPINB2;FGA;...
Nucleotide excision repair 1.78 1.87e-2 40/47 (85.11%) RAD23B;CCNH;ERCC5;...
Amyotrophic lateral sclerosis 1.77 1.73e-2 267/364 (73.35%) NDUFS4;RAB1A;MAPK14;...
Graft-versus-host disease 1.70 3.14e-2 32/42 (76.19%) HLA-DRA;HLA-DRB1;HLA-DPA1;...
Prion disease 1.70 3.06e-2 209/273 (76.56%) NDUFS4;MAPK14;CAV1;...
Protein export 1.69 2.93e-2 17/23 (73.91%) SRP72;OXA1L;SRP14;...
Staphylococcus aureus infection 1.69 2.87e-2 72/95 (75.79%) KRT13;HLA-DRA;HLA-DRB1;...
Protein processing in endoplasmic reticulum 1.67 3.20e-2 127/171 (74.27%) NFE2L2;RAD23B;TRAM1;...
Huntington disease 1.67 3.03e-2 233/306 (76.14%) NDUFS4;NDUFB5;PSMD3;...
Thiamine metabolism 1.63 3.96e-2 12/15 (80%) AK2;AK4;AK1;...
Basal transcription factors 1.63 4.00e-2 37/45 (82.22%) GTF2A2;GTF2B;CCNH;...
Autoimmune thyroid disease 1.62 4.08e-2 46/53 (86.79%) HLA-DRA;HLA-DRB1;HLA-DPA1;...
Thermogenesis 1.61 4.33e-2 173/232 (74.57%) NDUFS4;MAPK14;NDUFB5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 20uM 6H