Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMBWKL)

Drug Name
[3H]Ro154513 Drug Info
Synonyms
Ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Ro 15-4513; RO-154513; Ro15-4513; 91917-65-6; UNII-S5XGL82O5Y; S5XGL82O5Y; Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate; ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Ethyl 8-azido-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate; Ro-154513
Cross-matching ID
PubChem CID
5081
ChEBI ID
CHEMBL6597
CAS Number
CAS 91917-65-6
TTD Drug ID
D0M4CP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.14 9.00e-3 34/36 (94.44%) POLD1;RPA3;POLD2;...
Cell cycle 1.94 1.35e-2 110/124 (88.71%) CDC45;PLK1;ORC6;...
Mismatch repair 1.93 9.00e-3 22/23 (95.65%) EXO1;POLD1;RPA3;...
RNA transport 1.88 2.03e-2 128/186 (68.82%) EEF1A2;TACC3;CYFIP2;...
Base excision repair 1.86 1.80e-2 29/33 (87.88%) POLD1;POLD2;NEIL3;...
Homologous recombination 1.85 1.50e-2 35/41 (85.37%) POLD1;BRCA1;RPA3;...
Spliceosome 1.81 1.93e-2 101/150 (67.33%) SNRPD3;SRSF5;RBM25;...
Long-term depression 1.77 2.25e-2 55/60 (91.67%) GUCY1A1;GNAS;GRIA2;...
RNA degradation 1.77 2.10e-2 53/79 (67.09%) EXOSC4;TOB1;CNOT4;...
JAK-STAT signaling pathway -1.65 4.86e-2 146/162 (90.12%) IFNGR2;STAM;IL2RG;...
Ferroptosis -1.65 4.95e-2 36/41 (87.8%) FTH1;SAT1;CYBB;...
Protein processing in endoplasmic reticulum -1.66 4.80e-2 127/171 (74.27%) PPP1R15A;SEC13;AMFR;...
Steroid biosynthesis -1.67 4.45e-2 19/20 (95%) SC5D;CYP27B1;NSDHL;...
TNF signaling pathway -1.69 3.92e-2 103/112 (91.96%) IKBKG;MMP14;CREB3L2;...
Antigen processing and presentation -1.69 4.11e-2 60/78 (76.92%) NFYB;HLA-E;KIR3DL1;...
Various types of N-glycan biosynthesis -1.71 3.55e-2 26/39 (66.67%) MAN1A1;MGAT2;HEXB;...
N-Glycan biosynthesis -1.71 3.82e-2 38/50 (76%) MAN1A1;MGAT2;GANAB;...
Graft-versus-host disease -1.75 2.97e-2 32/42 (76.19%) HLA-E;KIR3DL1;CD80;...
Sphingolipid metabolism -1.78 2.16e-2 32/49 (65.31%) CERS4;GALC;SPHK1;...
Cytokine-cytokine receptor interaction -1.79 2.16e-2 246/295 (83.39%) IFNGR2;BMP7;IL2RG;...
Herpes simplex virus 1 infection -1.80 1.56e-2 165/498 (33.13%) TAP2;POU2F1;TRAF2;...
Ascorbate and aldarate metabolism -1.81 1.49e-2 15/30 (50%) UGT2A3;UGT2B17;ALDH1B1;...
Glycosaminoglycan biosynthesis -1.84 1.08e-2 40/58 (68.97%) CHPF2;B3GAT3;B4GALT3;...
Allograft rejection -1.91 7.21e-3 32/38 (84.21%) CD80;FAS;HLA-DQA1;...
Natural killer cell mediated cytotoxicity -1.91 8.65e-3 99/131 (75.57%) PTK2B;IFNAR2;CD247;...
Autoimmune thyroid disease -1.92 8.11e-3 46/53 (86.79%) IFNA17;FASLG;IL10;...
Intestinal immune network for IgA production -1.96 3.60e-3 38/48 (79.17%) TNFRSF13B;CD80;LTBR;...
Viral protein interaction with cytokine and cytokine re... -1.97 5.40e-3 84/100 (84%) CXCR1;TNFRSF10B;TNFRSF10D;...
Mineral absorption -2.39 0.00e+0 48/60 (80%) CYBRD1;MT1X;FTH1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H