Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMC0I7)

• Drug Name: METHIOTHEPIN Drug Info
• Synonyms: methiothepin; Metitepine; Methiothepine; Metitepinum; Metitepina; Metitepine [INN]; Metitepinum [INN-Latin]; Metitepina [INN-Spanish]; BRN 0626221; 20229-30-5; (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin; (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin; (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine; CHEBI:64203; 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine; NCGC00024665-03; DSSTox_CID_24000
• Cross-matching ID:
  PubChem CID: 4106
  ChEBI ID: CHEMBL93240
  CAS Number: CAS 20229-30-5
  TTD Drug ID: D0X6MT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.28	0.00e+0	76/85 (89.41%)	C3;F3;SERPINA5;...
Steroid biosynthesis	2.13	0.00e+0	19/20 (95%)	MSMO1;SQLE;DHCR24;...
Terpenoid backbone biosynthesis	2.00	3.20e-3	18/22 (81.82%)	IDI1;ACAT2;HMGCS1;...
Arachidonic acid metabolism	1.96	7.19e-3	48/61 (78.69%)	ALOX5;GPX2;AKR1C3;...
Pentose and glucuronate interconversions	1.91	5.75e-3	17/34 (50%)	AKR1B10;UGT2B28;UGT2B4;...
Biosynthesis of unsaturated fatty acids	1.88	4.79e-3	21/27 (77.78%)	SCD;ELOVL1;HACD1;...
PPAR signaling pathway	1.76	2.19e-2	66/74 (89.19%)	SCD;ACSL3;ME1;...
Oxidative phosphorylation	1.76	2.04e-2	93/133 (69.92%)	COX7B;ATP6V1H;NDUFA4;...
Lysosome	1.73	2.77e-2	115/128 (89.84%)	LAMP2;ASAH1;GAA;...
Steroid hormone biosynthesis	1.72	2.78e-2	43/61 (70.49%)	CYP1B1;UGT2B28;AKR1C3;...
Staphylococcus aureus infection	1.71	3.14e-2	72/95 (75.79%)	DEFB1;C3;KRT17;...
Type I diabetes mellitus	-1.80	4.95e-2	38/43 (88.37%)	IL12B;CD28;FASLG;...
Graft-versus-host disease	-1.89	1.06e-2	32/42 (76.19%)	CD28;FASLG;KLRD1;...
Allograft rejection	-1.95	2.12e-2	32/38 (84.21%)	IL12B;CD28;FASLG;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼