Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMC345)

Drug Name
Cefadroxil Drug Info
Synonyms
CDX; Cefadroxilo; Cefadroxilum; Cephadroxil; Sumacef; Cefadroxil anhydrous; S 578; BL-S 578; BL-S578; Cefadroxil (JP15); Cefadroxilo [INN-Spanish]; Cefadroxilum [INN-Latin]; Curisafe (TN); D-Cefadroxil; S-578; Sumacef (TN); MJF-11567-3; (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,4-didehydrocepham-4-carboxylic acid
Therapeutic ClassAntibiotics
Cross-matching ID
PubChem CID
47965
ChEBI ID
CHEMBL1644
CAS Number
CAS 50370-12-2
TTD Drug ID
D0X9ZC
VARIDT Drug ID
DR00313
INTEDE Drug ID
DR2413
ACDINA Drug ID
D00105

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NOD-like receptor signaling pathway -1.78 4.22e-2 145/181 (80.11%) STAT2;CASP8;CASP1;...
Autophagy -1.81 3.61e-2 113/169 (66.86%) AMBRA1;HMGB1;BECN1;...
NF-kappa B signaling pathway -1.83 2.96e-2 90/104 (86.54%) CCL13;TRAF6;TNFSF14;...
Linoleic acid metabolism -1.83 4.44e-2 21/29 (72.41%) PLA2G2D;CYP3A4;CYP2C9;...
FoxO signaling pathway -1.94 2.22e-2 118/131 (90.08%) INS;SIRT1;PRKAG2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H