Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMCL9F)

Drug Name
AZD1981 Drug Info
Synonyms
AZD1981; 802904-66-1; AZD-1981; UNII-2AD53WQ2CX; AZD 1981; 2AD53WQ2CX; CHEMBL1914489; 2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetic acid; 1H-Indole-1-acetic acid, 4-(acetylamino)-3-((4-chlorophenyl)thio)-2-methyl-; 1H-Indole-1-acetic acid, 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-; JWYIGNODXSRKGP-UHFFFAOYSA-N; GTPL7680; SCHEMBL1053662; EX-A662; MolPort-035-395-811; HMS3653A06; BCP20957; ZINC73196066; s7263; BDBM50357102; AKOS027263775; SB16902; DB11946; CS-4189; NCGC00386290-04; HY-15950; SC-94603
Cross-matching ID
PubChem CID
11292191
ChEBI ID
CHEMBL1914489
CAS Number
CAS 802904-66-1
TTD Drug ID
D0T4SG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
One carbon pool by folate 2.15 0.00e+0 15/20 (75%) TYMS;MTR;DHFR;...
DNA replication 2.11 0.00e+0 34/36 (94.44%) PCNA;MCM4;MCM6;...
Base excision repair 1.83 3.30e-2 29/33 (87.88%) PCNA;FEN1;HMGB1;...
Fructose and mannose metabolism 1.79 4.34e-2 30/33 (90.91%) PFKP;PFKL;PFKFB3;...
Pathways of neurodegeneration -1.70 3.25e-2 354/475 (74.53%) ATF6;ITPR2;SLC25A4;...
Type I diabetes mellitus -1.71 2.98e-2 38/43 (88.37%) HLA-DOA;IL1A;HLA-A;...
Alzheimer disease -1.73 2.54e-2 279/369 (75.61%) ATF6;ITPR2;SLC25A4;...
Staphylococcus aureus infection -1.74 2.40e-2 72/95 (75.79%) HLA-DMB;KRT19;MASP1;...
Hematopoietic cell lineage -1.74 2.41e-2 90/99 (90.91%) CSF2;IL5RA;HLA-DRB1;...
Antigen processing and presentation -1.76 2.00e-2 60/78 (76.92%) HLA-A;HSPA1L;KLRC3;...
Graft-versus-host disease -1.80 1.61e-2 32/42 (76.19%) HLA-DOA;IL1A;HLA-A;...
Allograft rejection -1.83 1.55e-2 32/38 (84.21%) CD40;GZMB;IL10;...
Prion disease -1.84 1.59e-2 209/273 (76.56%) NDUFB4;PSMA1;PSMD4;...
Mineral absorption -1.84 1.63e-2 48/60 (80%) SLC39A4;SLC30A1;VDR;...
Diabetic cardiomyopathy -1.90 1.04e-2 162/203 (79.8%) PPARA;NDUFB4;TGFBR1;...
Proteasome -1.91 8.74e-3 44/46 (95.65%) PSME3;PSMA1;PSMD4;...
Thermogenesis -1.92 8.33e-3 173/232 (74.57%) ACSL6;NDUFB4;PRKAG1;...
Huntington disease -2.02 3.89e-3 233/306 (76.14%) SLC25A4;SLC1A2;ATG2B;...
Non-alcoholic fatty liver disease -2.04 4.66e-3 126/155 (81.29%) PPARA;NDUFB4;PRKAG1;...
Asthma -2.05 5.83e-3 25/31 (80.65%) CD40;IL10;HLA-DOA;...
Parkinson disease -2.10 3.89e-3 176/249 (70.68%) NDUFB4;PSMA1;PSMD4;...
Vibrio cholerae infection -2.15 5.83e-3 44/50 (88%) PRKACB;ATP6V0C;KCNQ1;...
Oxidative phosphorylation -2.50 0.00e+0 93/133 (69.92%) NDUFS4;COX7C;SDHB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H