Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMD9QE)

• Drug Name: Colistin Drug Info
• Synonyms: Colistin sulphate; Polymyxin E; Colistin sulfate, nonsterile; Polymyxin E. Sulfate; Coly-Mycin M Parenteral (TN)
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 5311054
  CAS Number: CAS 1066-17-7
  TTD Drug ID: D0K7NQ
  INTEDE Drug ID: DR2644

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Progesterone-mediated oocyte maturation	2.16	0.00e+0	75/100 (75%)	CDC25B;PIK3R1;CCNB2;...
Regulation of lipolysis in adipocytes	1.96	0.00e+0	52/55 (94.55%)	FABP4;PLIN1;MGLL;...
Growth hormone synthesis, secretion and action	1.86	3.29e-2	108/119 (90.76%)	GHR;SST;GNAQ;...
ErbB signaling pathway	1.84	2.46e-2	79/85 (92.94%)	NCK1;PIK3R1;ERBB3;...
Platelet activation	1.79	3.45e-2	106/124 (85.48%)	COL1A1;COL1A2;GNAQ;...
Cysteine and methionine metabolism	-1.66	4.56e-2	43/50 (86%)	ENOPH1;AHCY;MDH2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	-1.66	4.94e-2	20/26 (76.92%)	PIGG;PIGP;PIGT;...
alpha-Linolenic acid metabolism	-1.70	3.59e-2	17/25 (68%)	PLA2G12A;ACAA1;ACOX3;...
Primary bile acid biosynthesis	-1.75	2.45e-2	15/17 (88.24%)	SLC27A5;SCP2;CYP7B1;...
Glycosaminoglycan degradation	-1.76	2.46e-2	19/19 (100%)	HYAL2;GUSB;HEXB;...
Staphylococcus aureus infection	-1.77	2.57e-2	72/95 (75.79%)	CFH;ITGAM;FCGR2A;...
Ferroptosis	-1.79	2.14e-2	36/41 (87.8%)	TF;MAP1LC3C;LPCAT3;...
Arginine biosynthesis	-1.82	1.84e-2	17/22 (77.27%)	GLS2;GOT1;ARG1;...
Mineral absorption	-1.82	2.21e-2	48/60 (80%)	SLC31A1;HMOX1;MT2A;...
Glycine, serine and threonine metabolism	-1.85	2.37e-2	31/40 (77.5%)	SRR;PSPH;GCAT;...
Rheumatoid arthritis	-1.93	1.05e-2	78/93 (83.87%)	TNFSF11;ANGPT1;ATP6V1D;...
Valine, leucine and isoleucine degradation	-1.95	1.19e-2	42/48 (87.5%)	ECHS1;AUH;BCKDHB;...
Steroid biosynthesis	-2.03	2.37e-2	19/20 (95%)	SC5D;FDFT1;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲