General Information of Drug (ID: DMME8LH)

Drug Name
Alitretinoin Drug Info
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
449171
ChEBI ID
CHEMBL705
CAS Number
CAS 5300-03-8
TTD Drug ID
D0G3PI
VARIDT Drug ID
DR00315
INTEDE Drug ID
DR2501

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.28 0.00e+0 34/36 (94.44%) RNASEH2A;RPA2;PCNA;...
Ribosome biogenesis in eukaryotes 2.26 0.00e+0 52/108 (48.15%) NXT1;IMP3;NHP2;...
Ribosome 2.17 0.00e+0 113/158 (71.52%) RPL10;RPS5;MRPS12;...
Mismatch repair 2.13 0.00e+0 22/23 (95.65%) RPA2;PCNA;MLH1;...
Spliceosome 2.12 0.00e+0 101/150 (67.33%) EIF4A3;PRPF8;SRSF7;...
Cytosolic DNA-sensing pathway 1.90 2.94e-3 52/63 (82.54%) POLR3K;PYCARD;POLR2H;...
TNF signaling pathway 1.85 8.81e-3 103/112 (91.96%) CCL2;CASP10;VCAM1;...
RNA degradation 1.83 9.91e-3 53/79 (67.09%) MTREX;LSM8;PFKP;...
Fanconi anemia pathway 1.83 8.81e-3 36/54 (66.67%) RPA2;PALB2;MLH1;...
RNA polymerase 1.80 1.32e-2 23/31 (74.19%) POLR3K;POLR2H;POLR2I;...
RNA transport 1.77 1.36e-2 128/186 (68.82%) NXT1;EIF4A3;RPP38;...
Base excision repair 1.76 1.62e-2 29/33 (87.88%) APEX1;PCNA;PARP1;...
Malaria 1.76 1.56e-2 44/50 (88%) CCL2;VCAM1;COMP;...
Viral protein interaction with cytokine and cytokine re... 1.75 1.45e-2 84/100 (84%) CCL2;TNFSF10;CXCL1;...
Proteasome 1.72 1.82e-2 44/46 (95.65%) PSMA7;PSMB6;PSMB4;...
N-Glycan biosynthesis 1.71 1.93e-2 38/50 (76%) ST6GAL1;MGAT4A;MAN1A1;...
IL-17 signaling pathway 1.70 2.02e-2 84/94 (89.36%) CCL2;CXCL1;CXCL5;...
Coronavirus disease 1.69 2.06e-2 215/232 (92.67%) CCL2;C3;F13A1;...
Graft-versus-host disease 1.69 2.04e-2 32/42 (76.19%) IL6;IL1B;HLA-DRB1;...
Influenza A 1.68 2.11e-2 156/172 (90.7%) CCL2;TMPRSS4;TNFSF10;...
Progesterone-mediated oocyte maturation 1.67 2.31e-2 75/100 (75%) BUB1;CDC25A;PRKACB;...
Mucin type O-glycan biosynthesis 1.65 2.64e-2 20/36 (55.56%) GCNT3;C1GALT1C1;GALNT14;...
Caffeine metabolism 1.64 2.57e-2 5/6 (83.33%) NAT1
Herpes simplex virus 1 infection 1.64 2.61e-2 165/498 (33.13%) CCL2;C3;SRSF7;...
Folate biosynthesis 1.62 3.42e-2 23/26 (88.46%) AKR1C3;AKR1B10;AKR1B1;...
Cell cycle 1.61 3.35e-2 110/124 (88.71%) SMAD3;MYC;ESPL1;...
Homologous recombination 1.59 4.08e-2 35/41 (85.37%) RPA2;PALB2;RPA3;...
Inflammatory bowel disease 1.58 4.37e-2 58/65 (89.23%) SMAD3;IFNGR1;IL6;...
Oxytocin signaling pathway -1.62 5.00e-2 128/154 (83.12%) ADCY8;PRKACA;PPP1CB;...
Melanoma -1.62 4.81e-2 68/72 (94.44%) EGF;AKT3;GADD45G;...
Metabolism of xenobiotics by cytochrome P450 -1.63 4.44e-2 49/77 (63.64%) ADH5;UGT2B17;UGT2B28;...
Glioma -1.66 3.80e-2 67/75 (89.33%) EGF;AKT3;GADD45G;...
Tyrosine metabolism -1.67 3.70e-2 30/36 (83.33%) TAT;TYR;ADH1C;...
Gastric acid secretion -1.67 3.72e-2 63/76 (82.89%) PLCB1;CCKBR;ADCY8;...
Glycine, serine and threonine metabolism -1.68 3.75e-2 31/40 (77.5%) CBS;PHGDH;SARDH;...
Porphyrin and chlorophyll metabolism -1.70 2.81e-2 23/43 (53.49%) COX15;UGT2A3;HEPH;...
Butanoate metabolism -1.71 2.70e-2 23/28 (82.14%) HADHA;AACS;ACAT1;...
Drug metabolism -1.74 2.39e-2 78/151 (51.66%) ADH5;UGT2B17;FMO5;...
Mineral absorption -1.74 2.50e-2 48/60 (80%) TRPM6;SLC34A2;ATP7A;...
PPAR signaling pathway -1.74 2.73e-2 66/74 (89.19%) SLC27A2;CYP27A1;CPT2;...
Bile secretion -1.81 1.56e-2 68/90 (75.56%) SLC5A1;SLCO1A2;ATP1B3;...
Ascorbate and aldarate metabolism -1.82 1.11e-2 15/30 (50%) KL;ALDH9A1;AKR1A1;...
Valine, leucine and isoleucine degradation -1.86 5.55e-3 42/48 (87.5%) HADHA;AACS;ACAT1;...
Terpenoid backbone biosynthesis -1.90 4.76e-3 18/22 (81.82%) ICMT;ACAT1;MVK;...
Fatty acid degradation -1.92 1.85e-3 40/43 (93.02%) ACAT1;ALDH9A1;ACOX3;...
Steroid biosynthesis -1.93 2.22e-3 19/20 (95%) SC5D;TM7SF2;DHCR24;...
Primary bile acid biosynthesis -2.03 0.00e+0 15/17 (88.24%) SLC27A5;SCP2;CYP39A1;...
Complement and coagulation cascades -2.03 0.00e+0 76/85 (89.41%) C8A;F2;MBL2;...
Peroxisome -2.05 0.00e+0 72/82 (87.8%) PEX5L;DECR2;EPHX2;...
Biosynthesis of unsaturated fatty acids -2.14 0.00e+0 21/27 (77.78%) ACOX3;ACOX1;SCP2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H