Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMMEAZ2)

Drug Name
RU-58841 Drug Info
Synonyms
154992-24-2; RU 58841; RU58841; 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; ARBYGDBJECGMGA-UHFFFAOYSA-N; UNII-0D8FJQ0ADW; 0D8FJQ0ADW; CHEMBL9337; 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile; AK-64424; 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile; Benzonitrile, 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-
Cross-matching ID
PubChem CID
132981
ChEBI ID
CHEMBL9337
CAS Number
CAS 154992-24-2
TTD Drug ID
D0L5KF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.06 0.00e+0 34/36 (94.44%) MCM5;RPA3;DNA2;...
Fanconi anemia pathway 1.82 2.33e-2 36/54 (66.67%) FANCI;RPA3;FANCL;...
Arginine biosynthesis 1.77 3.89e-2 17/22 (77.27%) ASS1;GLS;NOS3;...
Cell cycle 1.72 4.67e-2 110/124 (88.71%) CCNB2;MAD2L1;MCM5;...
Rheumatoid arthritis -1.70 4.30e-2 78/93 (83.87%) HLA-DRB1;ATP6V0C;TNFSF13;...
Salivary secretion -1.70 4.42e-2 76/93 (81.72%) GUCY1A1;ADRA1D;ITPR1;...
Vascular smooth muscle contraction -1.73 3.85e-2 113/133 (84.96%) MYH14;PPP1R12B;ADCY9;...
Allograft rejection -1.74 4.08e-2 32/38 (84.21%) HLA-G;HLA-DRB1;HLA-C;...
Phagosome -1.75 3.78e-2 118/152 (77.63%) CTSL;CALR;TUBA1A;...
Legionellosis -1.75 4.05e-2 51/57 (89.47%) ITGAM;CD14;EEF1A2;...
Propanoate metabolism -1.77 2.98e-2 30/34 (88.24%) MMUT;HADHA;BCKDHB;...
Autoimmune thyroid disease -1.78 3.20e-2 46/53 (86.79%) IFNA17;HLA-G;HLA-DRB1;...
Graft-versus-host disease -1.80 3.27e-2 32/42 (76.19%) KIR2DL1;HLA-G;HLA-DRB1;...
Cholesterol metabolism -1.82 2.80e-2 44/50 (88%) LRP2;APOC1;LDLR;...
Epithelial cell signaling in Helicobacter pylori infect... -1.82 3.50e-2 62/70 (88.57%) CHUK;ATP6V1A;MAPK14;...
Type I diabetes mellitus -1.87 3.74e-2 38/43 (88.37%) HLA-G;GAD1;HLA-DRB1;...
Bladder cancer -1.89 4.90e-2 40/41 (97.56%) DAPK2;MMP9;HRAS;...
Antigen processing and presentation -2.02 0.00e+0 60/78 (76.92%) KIR2DL1;CD8A;CTSL;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H